biostudies-literatureUnknown12(6)Borgonetti VMood disorders represent one of the most prevalent and costly psychiatric diseases worldwide. The current therapies are generally characterized by several well-known side effects which limit their prolonged use. The use of herbal medicine for the management of several psychiatric conditions is becoming more established, as it is considered a safer support to conventional pharmacotherapy. The aim of this study was to investigate the possible anxiolytic and antidepressant activity of a fixed combination of L-theanine, <i>Magnolia officinalis</i>, and <i>Melissa officinalis</i> (TMM) in an attempt to evaluate how the multiple modulations of different physiological systems may contribute to reducing mood disorders. TMM showed an anxiolytic-like and antidepressant-like activity in vivo, which wNutrientsE1803https://www.ebi.ac.uk/biostudies/studies/S-EPMC7353338biostudies-literatureNovel Therapeutic Approach for the Management of Mood Disorders: In Vivo and In Vitro Effect of a Combination of L-Theanine, <i>Melissa</i> <i>officinalis</i> L. and <i>Magnolia officinalis</i> Rehder & E.H. Wilson.PMC7353338Governa PBiagi MGaleotti NBorgonetti VfalseNovel Therapeutic Approach for the Management of Mood Disorders: In Vivo and In Vitro Effect of a Combination of L-Theanine, <i>Melissa</i> <i>officinalis</i> L. and <i>Magnolia officinalis</i> Rehder & E.H. Wilson.Mood disorders represent one of the most prevalent and costly psychiatric diseases worldwide. The current therapies are generally characterized by several well-known side effects which limit their prolonged use. The use of herbal medicine for the management of several psychiatric conditions is becoming more established, as it is considered a safer support to conventional pharmacotherapy. The aim of this study was to investigate the possible anxiolytic and antidepressant activity of a fixed combination of L-theanine, <i>Magnolia officinalis</i>, and <i>Melissa officinalis</i> (TMM) in an attempt to evaluate how the multiple modulations of different physiological systems may contribute to reducing mood disorders. TMM showed an anxiolytic-like and antidepressant-like activity in vivo, which w2020-01-01T00:00:00Z2020 Jun2026-05-03T00:08:46.532Z2020-11-22T12:30:37ZS-EPMC73533383256041310.3390/nu12061803