biostudies-literatureLee JYSoonchunhyang UniversityNational Research Foundation of Korea277https://www.ebi.ac.uk/biostudies/studies/S-EPMC7353728biostudies-literatureUnknown20(1)<h4>Background</h4>Dopamine transporter (DAT) imaging may enable clinicians to discriminate idiopathic normal pressure hydrocephalus (iNPH) from other parkinsonian disorders. However, a specific pattern of dopaminergic loss in DAT imaging of iNPH patients remains to be further elucidated.<h4>Methods</h4>In this preliminary study, 11 patients with iNPH in our hospital between March 2017 and February 2019 were finally enrolled. A diagnosis of iNPH was made according to the two established criteria. For visual analysis of DAT imaging, a striatum was divided into five domains. A semi-quantitative visual assessment was performed with a consensus between a nuclear medicine specialist and an experienced neurologist who were blinded to the clinical diagnosis.<h4>Results</h4>Striatal dopaminergic dBMC neurologyDetailed visual assessment of striatal dopaminergic depletion in patients with idiopathic normal pressure hydrocephalus: unremarkable or not?PMC7353728Not applicableNRF-2018R1C1B5045312Ju HKwon KYPark SBLee MLee JYIm KfalseDetailed visual assessment of striatal dopaminergic depletion in patients with idiopathic normal pressure hydrocephalus: unremarkable or not?<h4>Background</h4>Dopamine transporter (DAT) imaging may enable clinicians to discriminate idiopathic normal pressure hydrocephalus (iNPH) from other parkinsonian disorders. However, a specific pattern of dopaminergic loss in DAT imaging of iNPH patients remains to be further elucidated.<h4>Methods</h4>In this preliminary study, 11 patients with iNPH in our hospital between March 2017 and February 2019 were finally enrolled. A diagnosis of iNPH was made according to the two established criteria. For visual analysis of DAT imaging, a striatum was divided into five domains. A semi-quantitative visual assessment was performed with a consensus between a nuclear medicine specialist and an experienced neurologist who were blinded to the clinical diagnosis.<h4>Results</h4>Striatal dopaminergic d2020-01-01T00:00:00Z2020 Jul2025-05-29T14:37:49.243Z2024-10-19T04:22:10.374ZS-EPMC73537283265295910.1186/s12883-020-01861-7