biostudies-literatureAhmed MNIAID NIH HHSNHLBI NIH HHSNational Institutes of HealthNIH HHSeaay0233https://www.ebi.ac.uk/biostudies/studies/S-EPMC7354419biostudies-literatureUnknown12(528)One quarter of the world's population is infected with <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>), the causative agent of tuberculosis (TB). Although most infected individuals successfully control or clear the infection, some individuals will progress to TB disease. Immune correlates identified using animal models are not always effectively translated to human TB, thus resulting in a slow pace of translational discoveries from animal models to human TB for many platforms including vaccines, therapeutics, biomarkers, and diagnostic discovery. Therefore, it is critical to improve our poor understanding of immune correlates of disease and protection that are shared across animal TB models and human TB. In this study, we have provided an in-depth identification of the conserved and diversiScience translational medicineImmune correlates of tuberculosis disease and risk translate across species.PMC7354419P51 OD011104R01 AI111943R01 AI134236P51 OD011133AI111914-02U42 OD010442AI123780HL105427AI134236-02U19 AI091036R01 HL105427R01 AI123780U19 AI106772R01 AI111914Diamond MSMeans TDas SKhader SAAhmed MRangel-Moreno JLu LMitreva MThirunavukkarasu SThackray LBMartin JScriba TJMehra SMbandi SKThomas KARosa BAMurphy KMKaushal DfalseImmune correlates of tuberculosis disease and risk translate across species.One quarter of the world's population is infected with <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>), the causative agent of tuberculosis (TB). Although most infected individuals successfully control or clear the infection, some individuals will progress to TB disease. Immune correlates identified using animal models are not always effectively translated to human TB, thus resulting in a slow pace of translational discoveries from animal models to human TB for many platforms including vaccines, therapeutics, biomarkers, and diagnostic discovery. Therefore, it is critical to improve our poor understanding of immune correlates of disease and protection that are shared across animal TB models and human TB. In this study, we have provided an in-depth identification of the conserved and diversi2020-01-01T00:00:00Z2020 Jan2026-05-03T22:19:03.798Z2020-10-29T14:49:50ZS-EPMC73544193199646210.1126/scitranslmed.aay0233