{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jang Y"],"funding":["Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry"],"pagination":["E591"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7354466"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(6)"],"pubmed_abstract":["Ducks show notably higher resistance to highly pathogenic avian influenza viruses as compared to chickens. Here, we studied the age-dependent susceptibility in ducks to the infections caused by highly pathogenic avian influenza viruses. We intranasally infected ducks aged 1, 2, 4, and 8 weeks with highly pathogenic H5N6 avian influenza viruses isolated in South Korea in 2016. All the 1-and 2-week-old ducks died after infection, 20% of 3-week-old ducks died, and from the ducks aged 4 and 8 weeks, all of them survived. We performed microarray analysis and quantitative real-time PCR using total RNA isolated from the lungs of infected 2- and 4-week-old ducks to determine the mechanism underlying the age-dependent susceptibility to highly pathogenic avian influenza virus. Limited genes were fou"],"journal":["Viruses"],"pubmed_title":["Age-Dependent Lethality in Ducks Caused by Highly Pathogenic H5N6 Avian Influenza Virus."],"pmcid":["PMC7354466"],"funding_grant_id":["118092031SB010"],"pubmed_authors":["Jang Y","Seo SH"],"additional_accession":[]},"is_claimable":false,"name":"Age-Dependent Lethality in Ducks Caused by Highly Pathogenic H5N6 Avian Influenza Virus.","description":"Ducks show notably higher resistance to highly pathogenic avian influenza viruses as compared to chickens. Here, we studied the age-dependent susceptibility in ducks to the infections caused by highly pathogenic avian influenza viruses. We intranasally infected ducks aged 1, 2, 4, and 8 weeks with highly pathogenic H5N6 avian influenza viruses isolated in South Korea in 2016. All the 1-and 2-week-old ducks died after infection, 20% of 3-week-old ducks died, and from the ducks aged 4 and 8 weeks, all of them survived. We performed microarray analysis and quantitative real-time PCR using total RNA isolated from the lungs of infected 2- and 4-week-old ducks to determine the mechanism underlying the age-dependent susceptibility to highly pathogenic avian influenza virus. Limited genes were fou","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 May","modification":"2025-04-19T01:01:21.916Z","creation":"2025-04-07T11:57:52.036Z"},"accession":"S-EPMC7354466","cross_references":{"pubmed":["32485904"],"doi":["10.3390/v12060591"]}}