biostudies-literatureJang YKorea Institute of Planning and Evaluation for Technology in Food, Agriculture, ForestryE591https://www.ebi.ac.uk/biostudies/studies/S-EPMC7354466biostudies-literatureUnknown12(6)Ducks show notably higher resistance to highly pathogenic avian influenza viruses as compared to chickens. Here, we studied the age-dependent susceptibility in ducks to the infections caused by highly pathogenic avian influenza viruses. We intranasally infected ducks aged 1, 2, 4, and 8 weeks with highly pathogenic H5N6 avian influenza viruses isolated in South Korea in 2016. All the 1-and 2-week-old ducks died after infection, 20% of 3-week-old ducks died, and from the ducks aged 4 and 8 weeks, all of them survived. We performed microarray analysis and quantitative real-time PCR using total RNA isolated from the lungs of infected 2- and 4-week-old ducks to determine the mechanism underlying the age-dependent susceptibility to highly pathogenic avian influenza virus. Limited genes were fouVirusesAge-Dependent Lethality in Ducks Caused by Highly Pathogenic H5N6 Avian Influenza Virus.PMC7354466118092031SB010Jang YSeo SHfalseAge-Dependent Lethality in Ducks Caused by Highly Pathogenic H5N6 Avian Influenza Virus.Ducks show notably higher resistance to highly pathogenic avian influenza viruses as compared to chickens. Here, we studied the age-dependent susceptibility in ducks to the infections caused by highly pathogenic avian influenza viruses. We intranasally infected ducks aged 1, 2, 4, and 8 weeks with highly pathogenic H5N6 avian influenza viruses isolated in South Korea in 2016. All the 1-and 2-week-old ducks died after infection, 20% of 3-week-old ducks died, and from the ducks aged 4 and 8 weeks, all of them survived. We performed microarray analysis and quantitative real-time PCR using total RNA isolated from the lungs of infected 2- and 4-week-old ducks to determine the mechanism underlying the age-dependent susceptibility to highly pathogenic avian influenza virus. Limited genes were fou2020-01-01T00:00:00Z2020 May2025-04-19T01:01:21.916Z2025-04-07T11:57:52.036ZS-EPMC73544663248590410.3390/v12060591