{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(6)"],"submitter":["Eisenga MF"],"pubmed_abstract":["Elevated levels of erythropoietin (EPO) are associated with an increased risk of death in renal transplant recipients (RTRs), but the underlying mechanisms remain unclear. Emerging data suggest that EPO stimulates production of the phosphaturic hormone fibroblast growth factor 23 (FGF23), another strong risk factor for death in RTRs. We hypothesized that the hitherto unexplained association between EPO levels and adverse outcomes may be attributable to increased levels of FGF23. We included 579 RTRs (age 51 ± 12 years, 55% males) from the TransplantLines Insulin Resistance and Inflammation Cohort study (NCT03272854). During a follow-up of 7.0 years, 121 RTRs died, of which 62 were due to cardiovascular cause. In multivariable Cox regression analysis, EPO was independently associated with a"],"journal":["Journal of clinical medicine"],"pagination":["E1737"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7356141"],"repository":["biostudies-literature"],"pubmed_title":["Erythropoietin, Fibroblast Growth Factor 23, and Death After Kidney Transplantation."],"pmcid":["PMC7356141"],"pubmed_authors":["Gaillard CAJM","Eisenga MF","Nolte IM","Bakker SJL","Leaf DE","De Jong MA","De Borst MH"],"additional_accession":[]},"is_claimable":false,"name":"Erythropoietin, Fibroblast Growth Factor 23, and Death After Kidney Transplantation.","description":"Elevated levels of erythropoietin (EPO) are associated with an increased risk of death in renal transplant recipients (RTRs), but the underlying mechanisms remain unclear. Emerging data suggest that EPO stimulates production of the phosphaturic hormone fibroblast growth factor 23 (FGF23), another strong risk factor for death in RTRs. We hypothesized that the hitherto unexplained association between EPO levels and adverse outcomes may be attributable to increased levels of FGF23. We included 579 RTRs (age 51 ± 12 years, 55% males) from the TransplantLines Insulin Resistance and Inflammation Cohort study (NCT03272854). During a follow-up of 7.0 years, 121 RTRs died, of which 62 were due to cardiovascular cause. In multivariable Cox regression analysis, EPO was independently associated with a","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2025-04-27T02:58:55.988Z","creation":"2025-04-06T18:39:53.382Z"},"accession":"S-EPMC7356141","cross_references":{"pubmed":["32512806"],"doi":["10.3390/jcm9061737"]}}