{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Prado MKB"],"funding":["Conselho Nacional de Desenvolvimento Científico e Tecnológico","Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","Fundação de Amparo à Pesquisa do Estado de São Paulo"],"pagination":["E865"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7356283"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(6)"],"pubmed_abstract":["<i>Histoplasma capsulatum</i> is the agent of histoplasmosis, one of the most frequent mycoses in the world. The infection initiates with fungal spore inhalation, transformation into yeasts in the lungs and establishment of a granulomatous disease, which is characterized by a Th1 response. The production of Th1 signature cytokines, such as IFN-γ, is crucial for yeast clearance from the lungs, and to prevent dissemination. Recently, it was demonstrated that IL-17, a Th17 signature cytokine, is also important for fungal control, particularly in the absence of Th1 response. IL-22 is another cytokine with multiple functions on host response and disease progression. However, little is known about the role of IL-22 during histoplasmosis. In this study, we demonstrated that absence of IL-22 affec"],"journal":["Biomolecules"],"pubmed_title":["IL-22 Promotes IFN-γ-Mediated Immunity against <i>Histoplasma capsulatum</i> Infection."],"pmcid":["PMC7356283"],"funding_grant_id":["Finance Code 001","302514/2015-5","2014/07125-6 and 2015/00658-1"],"pubmed_authors":["Fontanari C","Souza COS","Zoccal KF","Meirelles AFG","Prado MKB","Ramos SG","Alves-Filho JC","Faccioli LH","Gardinassi LG","Peti APF","de Paula-Silva FWG","Sorgi CA"],"additional_accession":[]},"is_claimable":false,"name":"IL-22 Promotes IFN-γ-Mediated Immunity against <i>Histoplasma capsulatum</i> Infection.","description":"<i>Histoplasma capsulatum</i> is the agent of histoplasmosis, one of the most frequent mycoses in the world. The infection initiates with fungal spore inhalation, transformation into yeasts in the lungs and establishment of a granulomatous disease, which is characterized by a Th1 response. The production of Th1 signature cytokines, such as IFN-γ, is crucial for yeast clearance from the lungs, and to prevent dissemination. Recently, it was demonstrated that IL-17, a Th17 signature cytokine, is also important for fungal control, particularly in the absence of Th1 response. IL-22 is another cytokine with multiple functions on host response and disease progression. However, little is known about the role of IL-22 during histoplasmosis. In this study, we demonstrated that absence of IL-22 affec","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2025-04-26T07:09:02.119Z","creation":"2025-04-06T12:10:32.181Z"},"accession":"S-EPMC7356283","cross_references":{"pubmed":["32517114"],"doi":["10.3390/biom10060865"]}}