biostudies-literaturePrado MKBConselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFundação de Amparo à Pesquisa do Estado de São PauloE865https://www.ebi.ac.uk/biostudies/studies/S-EPMC7356283biostudies-literatureUnknown10(6)<i>Histoplasma capsulatum</i> is the agent of histoplasmosis, one of the most frequent mycoses in the world. The infection initiates with fungal spore inhalation, transformation into yeasts in the lungs and establishment of a granulomatous disease, which is characterized by a Th1 response. The production of Th1 signature cytokines, such as IFN-γ, is crucial for yeast clearance from the lungs, and to prevent dissemination. Recently, it was demonstrated that IL-17, a Th17 signature cytokine, is also important for fungal control, particularly in the absence of Th1 response. IL-22 is another cytokine with multiple functions on host response and disease progression. However, little is known about the role of IL-22 during histoplasmosis. In this study, we demonstrated that absence of IL-22 affecBiomoleculesIL-22 Promotes IFN-γ-Mediated Immunity against <i>Histoplasma capsulatum</i> Infection.PMC7356283Finance Code 001302514/2015-52014/07125-6 and 2015/00658-1Fontanari CSouza COSZoccal KFMeirelles AFGPrado MKBRamos SGAlves-Filho JCFaccioli LHGardinassi LGPeti APFde Paula-Silva FWGSorgi CAfalseIL-22 Promotes IFN-γ-Mediated Immunity against <i>Histoplasma capsulatum</i> Infection.<i>Histoplasma capsulatum</i> is the agent of histoplasmosis, one of the most frequent mycoses in the world. The infection initiates with fungal spore inhalation, transformation into yeasts in the lungs and establishment of a granulomatous disease, which is characterized by a Th1 response. The production of Th1 signature cytokines, such as IFN-γ, is crucial for yeast clearance from the lungs, and to prevent dissemination. Recently, it was demonstrated that IL-17, a Th17 signature cytokine, is also important for fungal control, particularly in the absence of Th1 response. IL-22 is another cytokine with multiple functions on host response and disease progression. However, little is known about the role of IL-22 during histoplasmosis. In this study, we demonstrated that absence of IL-22 affec2020-01-01T00:00:00Z2020 Jun2025-04-26T07:09:02.119Z2025-04-06T12:10:32.181ZS-EPMC73562833251711410.3390/biom10060865