{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Thounaojam MC"],"funding":["Eunice Kennedy Shriver National Institute of Child Health and Human Development","NEI NIH HHS","NICHD NIH HHS","National Eye Institute"],"pagination":["E1921"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7356323"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(6)"],"pubmed_abstract":["Retinopathy of prematurity (ROP) is the leading cause of blindness in infants. We have investigated the efficacy of the secondary bile acid ursodeoxycholic acid (UDCA) and its taurine and glycine conjugated derivatives tauroursodeoxycholic acid (TUDCA) and glycoursodeoxycholic acid (GUDCA) in preventing retinal neovascularization (RNV) in an experimental model of ROP. Seven-day-old mice pups (P7) were subjected to oxygen-induced retinopathy (OIR) and were treated with bile acids for various durations. Analysis of retinal vascular growth and distribution revealed that UDCA treatment (50 mg/kg, P7-P17) of OIR mice decreased the extension of neovascular and avascular areas, whereas treatments with TUDCA and GUDCA showed no changes. UDCA also prevented reactive gliosis, preserved ganglion cell"],"journal":["Journal of clinical medicine"],"pubmed_title":["Ursodeoxycholic Acid Halts Pathological Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy."],"pmcid":["PMC7356323"],"funding_grant_id":["R03 HD097660","R01 EY029318","EY028714","HD097660"],"pubmed_authors":["Rajpurohit S","Bartoli M","Jadeja RN","Martin PM","Thounaojam MC","Stansfield BK","Gutsaeva DR"],"additional_accession":[]},"is_claimable":false,"name":"Ursodeoxycholic Acid Halts Pathological Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy.","description":"Retinopathy of prematurity (ROP) is the leading cause of blindness in infants. We have investigated the efficacy of the secondary bile acid ursodeoxycholic acid (UDCA) and its taurine and glycine conjugated derivatives tauroursodeoxycholic acid (TUDCA) and glycoursodeoxycholic acid (GUDCA) in preventing retinal neovascularization (RNV) in an experimental model of ROP. Seven-day-old mice pups (P7) were subjected to oxygen-induced retinopathy (OIR) and were treated with bile acids for various durations. Analysis of retinal vascular growth and distribution revealed that UDCA treatment (50 mg/kg, P7-P17) of OIR mice decreased the extension of neovascular and avascular areas, whereas treatments with TUDCA and GUDCA showed no changes. UDCA also prevented reactive gliosis, preserved ganglion cell","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2026-06-06T23:05:00.665Z","creation":"2025-04-06T18:40:59.789Z"},"accession":"S-EPMC7356323","cross_references":{"pubmed":["32575487"],"doi":["10.3390/jcm9061921"]}}