biostudies-literatureUnknown25(12)Diaconu DTwo new series of hybrid quinoline-sulfonamide complexes (M2+: Zn2+, Cu2+, Co2+ and Cd2+) derivatives (QSC) were designed, synthesized and tested for their antimicrobial activity. The synthesis is straightforward and efficient, involving two steps: acylation of aminoquinoline followed by complexation with metal acetate (Cu2+, Co2+ and Cd2+) or chloride (Zn2+). The synthesized QSC compounds were characterized by FTIR and NMR spectroscopy and by X-ray diffraction on single crystal. The QSC compounds were preliminary screened for their antibacterial and antifungal activity and the obtained results are very promising. In this respect, the hybrid N-(quinolin-8-yl)-4-chloro-benzenesulfonamide cadmium (II), considered as leading structure for further studies, has an excellent antibacterial activiMolecules (Basel, Switzerland)E2946https://www.ebi.ac.uk/biostudies/studies/S-EPMC7356327biostudies-literatureHybrid Quinoline-Sulfonamide Complexes (M2+) Derivatives with Antimicrobial Activity.PMC7356327Antoci VMangalagiu VAmariucai-Mantu DMangalagiu IIDiaconu DGiuroiu CLfalseHybrid Quinoline-Sulfonamide Complexes (M2+) Derivatives with Antimicrobial Activity.Two new series of hybrid quinoline-sulfonamide complexes (M2+: Zn2+, Cu2+, Co2+ and Cd2+) derivatives (QSC) were designed, synthesized and tested for their antimicrobial activity. The synthesis is straightforward and efficient, involving two steps: acylation of aminoquinoline followed by complexation with metal acetate (Cu2+, Co2+ and Cd2+) or chloride (Zn2+). The synthesized QSC compounds were characterized by FTIR and NMR spectroscopy and by X-ray diffraction on single crystal. The QSC compounds were preliminary screened for their antibacterial and antifungal activity and the obtained results are very promising. In this respect, the hybrid N-(quinolin-8-yl)-4-chloro-benzenesulfonamide cadmium (II), considered as leading structure for further studies, has an excellent antibacterial activi2020-01-01T00:00:00Z2020 Jun2025-04-27T02:50:13.478Z2025-04-06T18:41:03.485ZS-EPMC73563273260482810.3390/molecules25122946