{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Park W"],"funding":["Chonbuk National University Hospital","National Research Foundation of Korea"],"pagination":["E563"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7356520"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(6)"],"pubmed_abstract":["Recent therapeutic strategies to suppress restenosis after biliary stent placement are insufficient. Here, we demonstrate the usefulness of a self-expandable metal stent (SEMS), a stent mesh coated with silver nanoparticles (AgNPs), for suppression of both stent-induced tissue hyperplasia and biliary sludge formation in the rabbit bile duct. The AgNP-coated SEMSs were prepared using a simple bio-inspired surface modification process. Then, the prepared SEMSs were successfully placed in 22 of 24 rabbits. Sludge formation in the AgNP-coated SEMS groups was significantly decreased compared to the control group on gross findings. Cholangiographic and histologic examinations demonstrated significantly decreased tissue hyperplasia in the AgNP-coated SEMS groups compared with the control group (p"],"journal":["Pharmaceutics"],"pubmed_title":["Metallic Stent Mesh Coated with Silver Nanoparticles Suppresses Stent-Induced Tissue Hyperplasia and Biliary Sludge in the Rabbit Extrahepatic Bile Duct."],"pmcid":["PMC7356520"],"funding_grant_id":["CUH2018-0015","2018R1C1B6001120"],"pubmed_authors":["Kim DH","Song HY","Park W","Kang JM","Kim SH","Park JH","Kim KY","Ryu DS","Lee SO"],"additional_accession":[]},"is_claimable":false,"name":"Metallic Stent Mesh Coated with Silver Nanoparticles Suppresses Stent-Induced Tissue Hyperplasia and Biliary Sludge in the Rabbit Extrahepatic Bile Duct.","description":"Recent therapeutic strategies to suppress restenosis after biliary stent placement are insufficient. Here, we demonstrate the usefulness of a self-expandable metal stent (SEMS), a stent mesh coated with silver nanoparticles (AgNPs), for suppression of both stent-induced tissue hyperplasia and biliary sludge formation in the rabbit bile duct. The AgNP-coated SEMSs were prepared using a simple bio-inspired surface modification process. Then, the prepared SEMSs were successfully placed in 22 of 24 rabbits. Sludge formation in the AgNP-coated SEMS groups was significantly decreased compared to the control group on gross findings. Cholangiographic and histologic examinations demonstrated significantly decreased tissue hyperplasia in the AgNP-coated SEMS groups compared with the control group (p","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2025-04-27T02:51:59.147Z","creation":"2025-04-06T18:41:32.338Z"},"accession":"S-EPMC7356520","cross_references":{"pubmed":["32560473"],"doi":["10.3390/pharmaceutics12060563"]}}