{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(6)"],"submitter":["Nigro E"],"pubmed_abstract":["Alterations of adipose tissue occurring in obesity have been recognized as a major risk factor for several cancers. The relationship between adipose tissue and lung cancer, which is the main cancer-related cause of death worldwide, still requires investigation. Perturbations in the adipokine system are likely to interfere with inter-organ crosstalk in lung cancer, which may influence the lung tumor microenvironment. Adiponectin (Acrp30) expression is deregulated in several cancer types. Acrp30 circulates as oligomers with a Low (LMW), Medium (MMW), and High Molecular Weight (HMW), with the latter mediating the main biological effects. Acrp30 acts through AdipoR1 and AdipoR2 receptors. T-cadherin has been described as a non-signaling receptor. This study's aim was to investigate the regulat"],"journal":["Biomolecules"],"pagination":["E926"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7356727"],"repository":["biostudies-literature"],"pubmed_title":["Implications of the Adiponectin System in Non-Small Cell Lung Cancer Patients: A Case-Control Study."],"pmcid":["PMC7356727"],"pubmed_authors":["Matera MG","Polito R","Pafundi PC","Daniele A","Nigro E","Perrotta F","Monaco ML","Bianco A"],"additional_accession":[]},"is_claimable":false,"name":"Implications of the Adiponectin System in Non-Small Cell Lung Cancer Patients: A Case-Control Study.","description":"Alterations of adipose tissue occurring in obesity have been recognized as a major risk factor for several cancers. The relationship between adipose tissue and lung cancer, which is the main cancer-related cause of death worldwide, still requires investigation. Perturbations in the adipokine system are likely to interfere with inter-organ crosstalk in lung cancer, which may influence the lung tumor microenvironment. Adiponectin (Acrp30) expression is deregulated in several cancer types. Acrp30 circulates as oligomers with a Low (LMW), Medium (MMW), and High Molecular Weight (HMW), with the latter mediating the main biological effects. Acrp30 acts through AdipoR1 and AdipoR2 receptors. T-cadherin has been described as a non-signaling receptor. This study's aim was to investigate the regulat","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2025-04-19T18:00:43.061Z","creation":"2020-11-22T12:30:18Z"},"accession":"S-EPMC7356727","cross_references":{"pubmed":["32570854"],"doi":["10.3390/biom10060926"]}}