biostudies-literatureUnknown10(6)Nigro EAlterations of adipose tissue occurring in obesity have been recognized as a major risk factor for several cancers. The relationship between adipose tissue and lung cancer, which is the main cancer-related cause of death worldwide, still requires investigation. Perturbations in the adipokine system are likely to interfere with inter-organ crosstalk in lung cancer, which may influence the lung tumor microenvironment. Adiponectin (Acrp30) expression is deregulated in several cancer types. Acrp30 circulates as oligomers with a Low (LMW), Medium (MMW), and High Molecular Weight (HMW), with the latter mediating the main biological effects. Acrp30 acts through AdipoR1 and AdipoR2 receptors. T-cadherin has been described as a non-signaling receptor. This study's aim was to investigate the regulatBiomoleculesE926https://www.ebi.ac.uk/biostudies/studies/S-EPMC7356727biostudies-literatureImplications of the Adiponectin System in Non-Small Cell Lung Cancer Patients: A Case-Control Study.PMC7356727Matera MGPolito RPafundi PCDaniele ANigro EPerrotta FMonaco MLBianco AfalseImplications of the Adiponectin System in Non-Small Cell Lung Cancer Patients: A Case-Control Study.Alterations of adipose tissue occurring in obesity have been recognized as a major risk factor for several cancers. The relationship between adipose tissue and lung cancer, which is the main cancer-related cause of death worldwide, still requires investigation. Perturbations in the adipokine system are likely to interfere with inter-organ crosstalk in lung cancer, which may influence the lung tumor microenvironment. Adiponectin (Acrp30) expression is deregulated in several cancer types. Acrp30 circulates as oligomers with a Low (LMW), Medium (MMW), and High Molecular Weight (HMW), with the latter mediating the main biological effects. Acrp30 acts through AdipoR1 and AdipoR2 receptors. T-cadherin has been described as a non-signaling receptor. This study's aim was to investigate the regulat2020-01-01T00:00:00Z2020 Jun2025-04-19T18:00:43.061Z2020-11-22T12:30:18ZS-EPMC73567273257085410.3390/biom10060926