{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rivas-Urbina A"],"funding":["Instituto de Salud Carlos III"],"pagination":["E829"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7356811"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(6)"],"pubmed_abstract":["Mimetic peptides are potential therapeutic agents for atherosclerosis. d-[113,114,115,116,117,118,119,120,121,122]apolipoprotein (apo) J (D-[113,114,115,116,117,118,119,120,121,122]apoJ) is a 10-residue peptide that is predicted to form a class G* amphipathic helix 6 from apoJ; it shows anti-inflammatory and anti-atherogenic properties. In the present study, we analyzed the effect of d-[113,114,115,116,117,118,119,120,121,122]apoJ in low-density lipoprotein receptor knockout mice(LDLR-KO) on the development of atherosclerosis and lipoprotein function. Fifteen-week-old female LDLR-KO mice fed an atherogenic Western-type diet were treated for eight weeks with d-[113,114,115,116,117,118,119,120,121,122]apoJ peptide, a scrambled peptide, or vehicle. Peptides were administered subcutaneously th"],"journal":["Biomolecules"],"pubmed_title":["Subcutaneous Administration of Apolipoprotein J-Derived Mimetic Peptide d-[113-122]apoJ Improves LDL and HDL Function and Prevents Atherosclerosis in LDLR-KO Mice."],"pmcid":["PMC7356811"],"funding_grant_id":["FI17/00031, CD12-00439, CP19/00146, CPII18/00004","PI13/00364, PI16/00471, PI17-00232, 502 PI16-00139 and CB07/08/0016"],"pubmed_authors":["Rivas-Urbina A","de Gonzalo-Calvo D","Julve J","Farre-Cabrerizo N","Perez A","Rull A","Aldana-Ramos J","Puig N","Santos D","Ordonez-Llanos J","Benitez S","Sanchez-Quesada JL","Escola-Gil JC"],"additional_accession":[]},"is_claimable":false,"name":"Subcutaneous Administration of Apolipoprotein J-Derived Mimetic Peptide d-[113-122]apoJ Improves LDL and HDL Function and Prevents Atherosclerosis in LDLR-KO Mice.","description":"Mimetic peptides are potential therapeutic agents for atherosclerosis. d-[113,114,115,116,117,118,119,120,121,122]apolipoprotein (apo) J (D-[113,114,115,116,117,118,119,120,121,122]apoJ) is a 10-residue peptide that is predicted to form a class G* amphipathic helix 6 from apoJ; it shows anti-inflammatory and anti-atherogenic properties. In the present study, we analyzed the effect of d-[113,114,115,116,117,118,119,120,121,122]apoJ in low-density lipoprotein receptor knockout mice(LDLR-KO) on the development of atherosclerosis and lipoprotein function. Fifteen-week-old female LDLR-KO mice fed an atherogenic Western-type diet were treated for eight weeks with d-[113,114,115,116,117,118,119,120,121,122]apoJ peptide, a scrambled peptide, or vehicle. Peptides were administered subcutaneously th","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 May","modification":"2025-04-19T18:00:53.835Z","creation":"2025-04-19T18:00:53.835Z"},"accession":"S-EPMC7356811","cross_references":{"pubmed":["32485898"],"doi":["10.3390/biom10060829"]}}