{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim Y"],"funding":["National Research Foundation of Korea"],"pagination":["E1694"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7356912"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(6)"],"pubmed_abstract":["This study aimed to understand the clinicopathological significance of runt-related transcription factor 1 (RUNX1) in non-small cell lung cancer (NSCLC). The methylation and mRNA levels of RUNX1 in NSCLC were determined using the Infinium HumanMethylation450 BeadChip and the HumanHT-12 expression BeadChip. RUNX1 protein levels were analyzed using immunohistochemistry of formalin-fixed paraffin-embedded tissues from 409 NSCLC patients. Three CpGs (cg04228935, cg11498607, and cg05000748) in the CpG island of RUNX1 showed significantly different methylation levels (Bonferroni corrected p < 0.05) between tumor and matched normal tissues obtained from 42 NSCLC patients. Methylation levels of the CpGs in the tumor tissues were inversely related to mRNA levels of RUNX1. A logistic regression mode"],"journal":["Journal of clinical medicine"],"pubmed_title":["Clinicopathological Significance of RUNX1 in Non-Small Cell Lung Cancer."],"pmcid":["PMC7356912"],"funding_grant_id":["2019R1F1A1057654"],"pubmed_authors":["Kim DH","Kim D","Um S","Lee BB","Kim Y","Cho EY","Han J","Shim YM"],"additional_accession":[]},"is_claimable":false,"name":"Clinicopathological Significance of RUNX1 in Non-Small Cell Lung Cancer.","description":"This study aimed to understand the clinicopathological significance of runt-related transcription factor 1 (RUNX1) in non-small cell lung cancer (NSCLC). The methylation and mRNA levels of RUNX1 in NSCLC were determined using the Infinium HumanMethylation450 BeadChip and the HumanHT-12 expression BeadChip. RUNX1 protein levels were analyzed using immunohistochemistry of formalin-fixed paraffin-embedded tissues from 409 NSCLC patients. Three CpGs (cg04228935, cg11498607, and cg05000748) in the CpG island of RUNX1 showed significantly different methylation levels (Bonferroni corrected p < 0.05) between tumor and matched normal tissues obtained from 42 NSCLC patients. Methylation levels of the CpGs in the tumor tissues were inversely related to mRNA levels of RUNX1. A logistic regression mode","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2025-04-26T08:15:30.594Z","creation":"2025-04-06T12:37:05.165Z"},"accession":"S-EPMC7356912","cross_references":{"pubmed":["32498288"],"doi":["10.3390/jcm9061694"]}}