{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Dong M"],"pubmed_abstract":["<h4>Background</h4>Previous studies on the systemic immune-inflammation index (SII), which is based on platelet, neutrophil and lymphocyte counts, as a prognostic marker in patients with colorectal cancer (CRC) yielded inconsistent results. The aim of this study was to evaluate the prognostic and clinicopathological role of SII in CRC <i>via</i> meta-analysis.<h4>Methods</h4>A comprehensive literature survey was performed on PubMed, Web of Science, Embase and the Cochrane Library databases to include studies published up to 6 April 2020. Pooled hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were computed to estimate the prognostic and clinicopathological value of SII in CRC.<h4>Results</h4>A total of 12 studies published between 2016 and 2019 were included in our meta-analysis. The combined analysis showed that high SII levels were significantly associated with worse overall survival (OS; HR = 1.61, 95% CI = 1.21-2.13, <i>p</i> = 0.001) and progression-free survival (HR = 1.74, 95% CI = 1.26-2.39, <i>p</i> = 0.001) in CRC. Moreover, elevated SII was also correlated with poor tumor differentiation (OR = 1.60, 95% CI = 1.27-2.02, <i>p</i> < 0.001), presence of distant metastasis (OR = 2.27, 95% CI = 1.10-4.67, <i>p</i> = 0.026), ECOG PS of 1-2 (OR = 1.98, 95% CI = 1.39-2.84, <i>p</i> < 0.001) and tumor size ⩾5 cm (OR = 1.49, 95% CI = 1.18-1.88, <i>p</i> = 0.001). However, high SII was not significantly associated with sex, tumor location, lymph node metastasis, or age in patients with CRC.<h4>Conclusion</h4>Our meta-analysis indicated that high SII levels predicted poor prognosis in CRC. In addition, an elevated SII was also associated with clinical factors, implying higher malignancy of the disease."],"journal":["Therapeutic advances in medical oncology"],"pagination":["1758835920937425"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7357045"],"repository":["biostudies-literature"],"pubmed_title":["Prognostic and clinicopathological significance of systemic immune-inflammation index in colorectal cancer: a meta-analysis."],"pmcid":["PMC7357045"],"pubmed_authors":["Mi Y","Yang J","Zhou Q","Gu X","Lian Y","Zhang Y","Wang D","Dong M","Ma T","Fan R","Shi Y"],"additional_accession":[]},"is_claimable":false,"name":"Prognostic and clinicopathological significance of systemic immune-inflammation index in colorectal cancer: a meta-analysis.","description":"<h4>Background</h4>Previous studies on the systemic immune-inflammation index (SII), which is based on platelet, neutrophil and lymphocyte counts, as a prognostic marker in patients with colorectal cancer (CRC) yielded inconsistent results. The aim of this study was to evaluate the prognostic and clinicopathological role of SII in CRC <i>via</i> meta-analysis.<h4>Methods</h4>A comprehensive literature survey was performed on PubMed, Web of Science, Embase and the Cochrane Library databases to include studies published up to 6 April 2020. Pooled hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were computed to estimate the prognostic and clinicopathological value of SII in CRC.<h4>Results</h4>A total of 12 studies published between 2016 and 2019 were included in our meta-analysis. The combined analysis showed that high SII levels were significantly associated with worse overall survival (OS; HR = 1.61, 95% CI = 1.21-2.13, <i>p</i> = 0.001) and progression-free survival (HR = 1.74, 95% CI = 1.26-2.39, <i>p</i> = 0.001) in CRC. Moreover, elevated SII was also correlated with poor tumor differentiation (OR = 1.60, 95% CI = 1.27-2.02, <i>p</i> < 0.001), presence of distant metastasis (OR = 2.27, 95% CI = 1.10-4.67, <i>p</i> = 0.026), ECOG PS of 1-2 (OR = 1.98, 95% CI = 1.39-2.84, <i>p</i> < 0.001) and tumor size ⩾5 cm (OR = 1.49, 95% CI = 1.18-1.88, <i>p</i> = 0.001). However, high SII was not significantly associated with sex, tumor location, lymph node metastasis, or age in patients with CRC.<h4>Conclusion</h4>Our meta-analysis indicated that high SII levels predicted poor prognosis in CRC. In addition, an elevated SII was also associated with clinical factors, implying higher malignancy of the disease.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-19T18:01:41.525Z","creation":"2025-04-19T18:01:41.525Z"},"accession":"S-EPMC7357045","cross_references":{"pubmed":["32699557"],"doi":["10.1177/1758835920937425"]}}