biostudies-literatureUnknown12Dong M<h4>Background</h4>Previous studies on the systemic immune-inflammation index (SII), which is based on platelet, neutrophil and lymphocyte counts, as a prognostic marker in patients with colorectal cancer (CRC) yielded inconsistent results. The aim of this study was to evaluate the prognostic and clinicopathological role of SII in CRC <i>via</i> meta-analysis.<h4>Methods</h4>A comprehensive literature survey was performed on PubMed, Web of Science, Embase and the Cochrane Library databases to include studies published up to 6 April 2020. Pooled hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were computed to estimate the prognostic and clinicopathological value of SII in CRC.<h4>Results</h4>A total of 12 studies published between 2016 and 2019 were included in our meta-analysis. The combined analysis showed that high SII levels were significantly associated with worse overall survival (OS; HR = 1.61, 95% CI = 1.21-2.13, <i>p</i> = 0.001) and progression-free survival (HR = 1.74, 95% CI = 1.26-2.39, <i>p</i> = 0.001) in CRC. Moreover, elevated SII was also correlated with poor tumor differentiation (OR = 1.60, 95% CI = 1.27-2.02, <i>p</i> < 0.001), presence of distant metastasis (OR = 2.27, 95% CI = 1.10-4.67, <i>p</i> = 0.026), ECOG PS of 1-2 (OR = 1.98, 95% CI = 1.39-2.84, <i>p</i> < 0.001) and tumor size ⩾5 cm (OR = 1.49, 95% CI = 1.18-1.88, <i>p</i> = 0.001). However, high SII was not significantly associated with sex, tumor location, lymph node metastasis, or age in patients with CRC.<h4>Conclusion</h4>Our meta-analysis indicated that high SII levels predicted poor prognosis in CRC. In addition, an elevated SII was also associated with clinical factors, implying higher malignancy of the disease.Therapeutic advances in medical oncology1758835920937425https://www.ebi.ac.uk/biostudies/studies/S-EPMC7357045biostudies-literaturePrognostic and clinicopathological significance of systemic immune-inflammation index in colorectal cancer: a meta-analysis.PMC7357045Mi YYang JZhou QGu XLian YZhang YWang DDong MMa TFan RShi YfalsePrognostic and clinicopathological significance of systemic immune-inflammation index in colorectal cancer: a meta-analysis.<h4>Background</h4>Previous studies on the systemic immune-inflammation index (SII), which is based on platelet, neutrophil and lymphocyte counts, as a prognostic marker in patients with colorectal cancer (CRC) yielded inconsistent results. The aim of this study was to evaluate the prognostic and clinicopathological role of SII in CRC <i>via</i> meta-analysis.<h4>Methods</h4>A comprehensive literature survey was performed on PubMed, Web of Science, Embase and the Cochrane Library databases to include studies published up to 6 April 2020. Pooled hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were computed to estimate the prognostic and clinicopathological value of SII in CRC.<h4>Results</h4>A total of 12 studies published between 2016 and 2019 were included in our meta-analysis. The combined analysis showed that high SII levels were significantly associated with worse overall survival (OS; HR = 1.61, 95% CI = 1.21-2.13, <i>p</i> = 0.001) and progression-free survival (HR = 1.74, 95% CI = 1.26-2.39, <i>p</i> = 0.001) in CRC. Moreover, elevated SII was also correlated with poor tumor differentiation (OR = 1.60, 95% CI = 1.27-2.02, <i>p</i> < 0.001), presence of distant metastasis (OR = 2.27, 95% CI = 1.10-4.67, <i>p</i> = 0.026), ECOG PS of 1-2 (OR = 1.98, 95% CI = 1.39-2.84, <i>p</i> < 0.001) and tumor size ⩾5 cm (OR = 1.49, 95% CI = 1.18-1.88, <i>p</i> = 0.001). However, high SII was not significantly associated with sex, tumor location, lymph node metastasis, or age in patients with CRC.<h4>Conclusion</h4>Our meta-analysis indicated that high SII levels predicted poor prognosis in CRC. In addition, an elevated SII was also associated with clinical factors, implying higher malignancy of the disease.2020-01-01T00:00:00Z20202025-04-19T18:01:41.525Z2025-04-19T18:01:41.525ZS-EPMC73570453269955710.1177/1758835920937425