biostudies-literatureTorgersen JNational Institutes on Alcohol Abuse and AlcoholismNCATS NIH HHSNational Cancer InstituteNIAAA NIH HHSNCI NIH HHS747-755https://www.ebi.ac.uk/biostudies/studies/S-EPMC7357318biostudies-literatureUnknown112(7)<h4>Background</h4>Despite increasing incidence of hepatocellular carcinoma (HCC) among HIV-infected patients, it remains unclear if HIV-related factors contribute to development of HCC. We examined if higher or prolonged HIV viremia and lower CD4+ cell percentage were associated with HCC.<h4>Methods</h4>We conducted a cohort study of HIV-infected individuals who had HIV RNA, CD4+, and CD8+ cell counts and percentages assessed in the Veterans Aging Cohort Study (1999-2015). HCC was ascertained using Veterans Health Administration cancer registries and electronic records. Cox regression was used to determine hazard ratios (HR, 95% confidence interval [CI]) of HCC associated with higher current HIV RNA, longer duration of detectable HIV viremia (≥500 copies/mL), and current CD4+ cell percentJournal of the National Cancer InstituteHIV RNA, CD4+ Percentage, and Risk of Hepatocellular Carcinoma by Cirrhosis Status.PMC7357318U01 AA013566UL1 TR001863U01AA013566R01 CA206465R01CA206465Rodriguez-Barradas MCBrau NCarbonari DMGoetz MBMehta RLTate JPJustice ACLo Re VGibert CLPark LSKallan MJD'Addeo KBrown STRoy JATaddei THLim JKTorgersen JfalseHIV RNA, CD4+ Percentage, and Risk of Hepatocellular Carcinoma by Cirrhosis Status.<h4>Background</h4>Despite increasing incidence of hepatocellular carcinoma (HCC) among HIV-infected patients, it remains unclear if HIV-related factors contribute to development of HCC. We examined if higher or prolonged HIV viremia and lower CD4+ cell percentage were associated with HCC.<h4>Methods</h4>We conducted a cohort study of HIV-infected individuals who had HIV RNA, CD4+, and CD8+ cell counts and percentages assessed in the Veterans Aging Cohort Study (1999-2015). HCC was ascertained using Veterans Health Administration cancer registries and electronic records. Cox regression was used to determine hazard ratios (HR, 95% confidence interval [CI]) of HCC associated with higher current HIV RNA, longer duration of detectable HIV viremia (≥500 copies/mL), and current CD4+ cell percent2020-01-01T00:00:00Z2020 Jul2025-04-04T08:18:31.162Z2020-11-08T09:45:25ZS-EPMC73573183168775510.1093/jnci/djz214