{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cienfuegos-Pecina E"],"funding":["Liver Unit and the Department of Analytical Chemistry","National Council of Science and Technology"],"pagination":["e9438"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7357568"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8"],"pubmed_abstract":["<h4>Background</h4>Ischemia-reperfusion (IR) injury is the main cause of delayed graft function in solid organ transplantation. Hypoxia-inducible factors (HIFs) control the expression of genes related to preconditioning against IR injury. During normoxia, HIF-α subunits are marked for degradation by the egg-laying defective nine homolog (EGLN) family of prolyl-4-hydroxylases. The inhibition of EGLN stabilizes HIFs and protects against IR injury. The aim of this study was to determine whether the EGLN inhibitors sodium (<i>S</i>)-2-hydroxyglutarate [(<i>S</i>)-2HG] and succinic acid (SA) have a nephroprotective effect against renal IR injury in Wistar rats.<h4>Methods</h4>(<i>S</i>)-2HG was synthesized in a 22.96% yield from commercially available L-glutamic acid in a two-step methodology ("],"journal":["PeerJ"],"pubmed_title":["Effect of sodium (<i>S</i>)-2-hydroxyglutarate in male, and succinic acid in female Wistar rats against renal ischemia-reperfusion injury, suggesting a role of the HIF-1 pathway."],"pmcid":["PMC7357568"],"funding_grant_id":["2017-01-5652"],"pubmed_authors":["Munoz-Espinosa LE","Perez-Rodriguez E","Dominguez-Vazquez I","Alarcon-Galvan G","Saucedo AL","Esquivel-Figueroa D","Ibarra-Rivera TR","Rodriguez-Rodriguez DR","Alcantara-Solano KJ","Torres-Gonzalez L","Ramirez-Martinez LA","Cienfuegos-Pecina E","Moreno-Pena DP","Cordero-Perez P"],"additional_accession":[]},"is_claimable":false,"name":"Effect of sodium (<i>S</i>)-2-hydroxyglutarate in male, and succinic acid in female Wistar rats against renal ischemia-reperfusion injury, suggesting a role of the HIF-1 pathway.","description":"<h4>Background</h4>Ischemia-reperfusion (IR) injury is the main cause of delayed graft function in solid organ transplantation. Hypoxia-inducible factors (HIFs) control the expression of genes related to preconditioning against IR injury. During normoxia, HIF-α subunits are marked for degradation by the egg-laying defective nine homolog (EGLN) family of prolyl-4-hydroxylases. The inhibition of EGLN stabilizes HIFs and protects against IR injury. The aim of this study was to determine whether the EGLN inhibitors sodium (<i>S</i>)-2-hydroxyglutarate [(<i>S</i>)-2HG] and succinic acid (SA) have a nephroprotective effect against renal IR injury in Wistar rats.<h4>Methods</h4>(<i>S</i>)-2HG was synthesized in a 22.96% yield from commercially available L-glutamic acid in a two-step methodology (","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-19T18:01:37.166Z","creation":"2025-04-19T18:01:37.166Z"},"accession":"S-EPMC7357568","cross_references":{"pubmed":["32728491"],"doi":["10.7717/peerj.9438"]}}