{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Enkhmaa B"],"funding":["NICHD NIH HHS","NCATS NIH HHS","NHLBI NIH HHS","Women’s Health Program Award","National Institutes of Health","UC Davis Clinical and Translational Center"],"pagination":["bvaa073"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7358566"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(7)"],"pubmed_abstract":["<h4>Context</h4>Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) reduces lipoprotein(a) [Lp(a)] levels, but the association of PCSK9 with Lp(a) level and its major determinant, apolipoprotein(a) [apo(a)] size, is not fully understood.<h4>Objective</h4>To assess the relationship between PCSK9, Lp(a) level, apo(a) size, age, and ethnicity/race.<h4>Design</h4>Cross-sectional.<h4>Setting</h4>General population.<h4>Participants</h4>Healthy African Americans and Caucasians (n = 267); age range: 6 to 74 years.<h4>Interventions</h4>None.<h4>Main outcome measures</h4>PCSK9 levels, apo(a) isoform and <i>LPA</i> allele sizes, and isoform-specific Lp(a) levels.<h4>Results</h4>Plasma PCSK9 levels were significantly higher in African Americans vs Caucasians, in females vs males, and i"],"journal":["Journal of the Endocrine Society"],"pubmed_title":["PCSK9 in African Americans and Caucasians in Relation to Lp(a) Level, Apo(a) Size and Heritability."],"pmcid":["PMC7358566"],"funding_grant_id":["#TR001860","R01#HL62705","UL1 TR001860","R01 HL062705","K12 HD051958","#NIH 2K12HD051958"],"pubmed_authors":["Zhang W","Prakash N","Berglund L","Kim K","Anuurad E","Enkhmaa B","Truax K"],"additional_accession":[]},"is_claimable":false,"name":"PCSK9 in African Americans and Caucasians in Relation to Lp(a) Level, Apo(a) Size and Heritability.","description":"<h4>Context</h4>Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) reduces lipoprotein(a) [Lp(a)] levels, but the association of PCSK9 with Lp(a) level and its major determinant, apolipoprotein(a) [apo(a)] size, is not fully understood.<h4>Objective</h4>To assess the relationship between PCSK9, Lp(a) level, apo(a) size, age, and ethnicity/race.<h4>Design</h4>Cross-sectional.<h4>Setting</h4>General population.<h4>Participants</h4>Healthy African Americans and Caucasians (n = 267); age range: 6 to 74 years.<h4>Interventions</h4>None.<h4>Main outcome measures</h4>PCSK9 levels, apo(a) isoform and <i>LPA</i> allele sizes, and isoform-specific Lp(a) levels.<h4>Results</h4>Plasma PCSK9 levels were significantly higher in African Americans vs Caucasians, in females vs males, and i","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2025-04-04T23:46:35.988Z","creation":"2025-04-04T23:46:35.988Z"},"accession":"S-EPMC7358566","cross_references":{"pubmed":["32685870"],"doi":["10.1210/jendso/bvaa073"]}}