{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Netto E"],"funding":["Instituto Português de Oncologia de Lisboa Francisco Gentil Research Fund"],"pagination":["746-753"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7358631"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(5)"],"pubmed_abstract":["<h4>Aim</h4>Report our results of biomarker discovery in formalin-fixed paraffin-embedded (FFPE) nasopharyngeal carcinoma (NPC) via proteomic analysis.<h4>Background</h4>Nasopharyngeal carcinoma (NPC) is a rare cancer in Western countries. Proteomic analysis have already been reported as a useful tool to provide biomarkers. Formalin-fixed paraffin-embedded (FFPE) samples, despite largely underused, can provide invaluable information for biomarker research via proteomic analysis.<h4>Methods</h4>FFPE samples of NPC were submitted to protein extraction followed by FASP-digestion and label-free quantitative mass spectrometry (MS). Patients' received concurrent chemoradiation with or without adjuvant chemotherapy as per Intergroup 0099 trial. IMRT was delivered following the RTOG0615 specificat"],"journal":["Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology"],"pubmed_title":["Label-free quantitative mass spectrometry from formalin-fixed paraffin-embedded samples of nasopharyngeal carcinoma: Preliminary results from a non-endemic European cohort of patients."],"pmcid":["PMC7358631"],"funding_grant_id":["2015/UIC901"],"pubmed_authors":["Carvalho L","Rito M","Cabecadas J","Netto E","Santos H","Capelo-Martinez JL","Roldao M"],"additional_accession":[]},"is_claimable":false,"name":"Label-free quantitative mass spectrometry from formalin-fixed paraffin-embedded samples of nasopharyngeal carcinoma: Preliminary results from a non-endemic European cohort of patients.","description":"<h4>Aim</h4>Report our results of biomarker discovery in formalin-fixed paraffin-embedded (FFPE) nasopharyngeal carcinoma (NPC) via proteomic analysis.<h4>Background</h4>Nasopharyngeal carcinoma (NPC) is a rare cancer in Western countries. Proteomic analysis have already been reported as a useful tool to provide biomarkers. Formalin-fixed paraffin-embedded (FFPE) samples, despite largely underused, can provide invaluable information for biomarker research via proteomic analysis.<h4>Methods</h4>FFPE samples of NPC were submitted to protein extraction followed by FASP-digestion and label-free quantitative mass spectrometry (MS). Patients' received concurrent chemoradiation with or without adjuvant chemotherapy as per Intergroup 0099 trial. IMRT was delivered following the RTOG0615 specificat","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Sep-Oct","modification":"2025-04-05T12:03:23.049Z","creation":"2022-02-11T09:59:54.656Z"},"accession":"S-EPMC7358631","cross_references":{"pubmed":["32684864"],"doi":["10.1016/j.rpor.2020.05.007"]}}