{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(17)"],"submitter":["Bajpai VK"],"pubmed_abstract":["<b>Rationale:</b> The present study reports the multifunctional anticancer activity against B16F10 melanoma cancer cells and the bioimaging ability of fluorescent nitrogen-phosphorous-doped carbon dots (NPCDs). <b>Methods:</b> The NPCDs were synthesized using a single-step, thermal treatment and were characterized by TEM, XPS, fluorescence and UV-Vis spectroscopy, and FTIR analysis. The anticancer efficacy of NPCDs was confirmed by using cell viability assay, morphological evaluation, fluorescent live-dead cell assay, mitochondrial potential assay, ROS production, RT-PCR, western-blot analysis, siRNA transfection, and cellular bioimaging ability. <b>Results:</b> The NPCDs inhibited the proliferation of B16F10 melanoma cancer cells after 24 h of treatment and induced apoptosis, as confirmed"],"journal":["Theranostics"],"pagination":["7841-7856"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7359102"],"repository":["biostudies-literature"],"pubmed_title":["Multifunctional N-P-doped carbon dots for regulation of apoptosis and autophagy in B16F10 melanoma cancer cells and <i>in vitro</i> imaging applications."],"pmcid":["PMC7359102"],"pubmed_authors":["Suk Huh Y","Aziz F","Tripathi KM","Chen L","Sonkar SK","Khan I","Shukla S","Bajpai VK","Cho HJ","Su Heo N","Han YK","Saini D","Kang SM"],"additional_accession":[]},"is_claimable":false,"name":"Multifunctional N-P-doped carbon dots for regulation of apoptosis and autophagy in B16F10 melanoma cancer cells and <i>in vitro</i> imaging applications.","description":"<b>Rationale:</b> The present study reports the multifunctional anticancer activity against B16F10 melanoma cancer cells and the bioimaging ability of fluorescent nitrogen-phosphorous-doped carbon dots (NPCDs). <b>Methods:</b> The NPCDs were synthesized using a single-step, thermal treatment and were characterized by TEM, XPS, fluorescence and UV-Vis spectroscopy, and FTIR analysis. The anticancer efficacy of NPCDs was confirmed by using cell viability assay, morphological evaluation, fluorescent live-dead cell assay, mitochondrial potential assay, ROS production, RT-PCR, western-blot analysis, siRNA transfection, and cellular bioimaging ability. <b>Results:</b> The NPCDs inhibited the proliferation of B16F10 melanoma cancer cells after 24 h of treatment and induced apoptosis, as confirmed","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-04T03:20:28.831Z","creation":"2020-08-30T07:16:47Z"},"accession":"S-EPMC7359102","cross_references":{"pubmed":["32685024"],"doi":["10.7150/thno.42291"]}}