{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Taieb J"],"funding":["National Cancer Institute at the National Institutes of Health","NCI NIH HHS"],"pagination":["1466-1471"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7360150"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(9)"],"pubmed_abstract":["<h4>Background</h4>Microsatellite instable/deficient mismatch repair (MSI/dMMR) metastatic colorectal cancers have been reported to have a poor prognosis. Frequent co-occurrence of MSI/dMMR and BRAFV600E complicates the association.<h4>Patients and methods</h4>Patients with resected stage III colon cancer (CC) from seven adjuvant studies with available data for disease recurrence and MMR and BRAFV600E status were analyzed. The primary end point was survival after recurrence (SAR). Associations of markers with SAR were analyzed using Cox proportional hazards models adjusted for age, gender, performance status, T stage, N stage, primary tumor location, grade, KRAS status, and timing of recurrence.<h4>Results</h4>Among 2630 patients with cancer recurrence (1491 men [56.7%], mean age, 58.5 [19"],"journal":["Annals of oncology : official journal of the European Society for Medical Oncology"],"pubmed_title":["Prognosis of microsatellite instability and/or mismatch repair deficiency stage III colon cancer patients after disease recurrence following adjuvant treatment: results of an ACCENT pooled analysis of seven studies."],"pmcid":["PMC7360150"],"funding_grant_id":["U10 CA180882","U10CA180882"],"pubmed_authors":["Grothey A","Shi Q","Lonardi S","Zaanan A","Taieb J","Kerr R","Pederson L","Alberts S","Van Cutsem E","Sinicrope FA","de Gramont A","Wolmark N","Andre T","Yoshino T","Yothers G"],"additional_accession":[]},"is_claimable":false,"name":"Prognosis of microsatellite instability and/or mismatch repair deficiency stage III colon cancer patients after disease recurrence following adjuvant treatment: results of an ACCENT pooled analysis of seven studies.","description":"<h4>Background</h4>Microsatellite instable/deficient mismatch repair (MSI/dMMR) metastatic colorectal cancers have been reported to have a poor prognosis. Frequent co-occurrence of MSI/dMMR and BRAFV600E complicates the association.<h4>Patients and methods</h4>Patients with resected stage III colon cancer (CC) from seven adjuvant studies with available data for disease recurrence and MMR and BRAFV600E status were analyzed. The primary end point was survival after recurrence (SAR). Associations of markers with SAR were analyzed using Cox proportional hazards models adjusted for age, gender, performance status, T stage, N stage, primary tumor location, grade, KRAS status, and timing of recurrence.<h4>Results</h4>Among 2630 patients with cancer recurrence (1491 men [56.7%], mean age, 58.5 [19","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2026-06-15T06:07:40.601Z","creation":"2026-06-15T03:08:12.66Z"},"accession":"S-EPMC7360150","cross_references":{"pubmed":["31268130"],"doi":["10.1093/annonc/mdz208"]}}