{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gutierrez-Pliego LE"],"funding":["Universidad Autónoma del Estado de México"],"pagination":["728-735"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7360907"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(5)"],"pubmed_abstract":["<h4>Background</h4>Type 2 Diabetes Mellitus (T2DM) is considered a chronic noncommunicable disease in which oxidative stress is expected as a result of hyperglycaemia. One of the most recent approaches is the study of microalgae fatty acids and their possible antioxidant effect.<h4>Objective</h4>This study aimed to analyse the effect of supplementation with n-3 fatty acids extracted from microalgae on the total antioxidant capacity (TAC) and lipid peroxidation of adipose tissue and plasma from diabetic (db/db) and healthy (CD1) mice.<h4>Methods</h4>Mice were supplemented with lyophilized n-3 fatty acids extracted from microalgae or added to the diet, from week 8 to 16. TAC assay and Thiobarbituric Acid Reactive Substances assay (TBARS) were performed on adipose tissue and plasma samples.<h4>Results</h4>The supplementation of lyophilized n-3 fatty acids from microalgae increased the total antioxidant capacity in adipose tissue of diabetic mice (615.67μM Trolox equivalents vs 405.02μM Trolox equivalents from control mice, p<0.01) and in the plasma of healthy mice (1132.97±85.75μM Trolox equivalents vs 930.64±32μM Trolox equivalents from modified diet mice, p<0.01). There was no significant effect on lipid peroxidation on both strains.<h4>Conclusion</h4>The use of n-3 fatty acids extracted from microalgae could be a useful strategy to improve total antioxidant capacity in T2DM."],"journal":["Endocrine, metabolic & immune disorders drug targets"],"pubmed_title":["Effect on Adipose Tissue of Diabetic Mice Supplemented with n-3 Fatty Acids Extracted from Microalgae."],"pmcid":["PMC7360907"],"funding_grant_id":["UAEM 4507/2018/CI"],"pubmed_authors":["Resendiz-Albor AA","Gutierrez-Pliego LE","Valdes-Ramos R","Martinez-Carrillo BE"],"additional_accession":[]},"is_claimable":false,"name":"Effect on Adipose Tissue of Diabetic Mice Supplemented with n-3 Fatty Acids Extracted from Microalgae.","description":"<h4>Background</h4>Type 2 Diabetes Mellitus (T2DM) is considered a chronic noncommunicable disease in which oxidative stress is expected as a result of hyperglycaemia. One of the most recent approaches is the study of microalgae fatty acids and their possible antioxidant effect.<h4>Objective</h4>This study aimed to analyse the effect of supplementation with n-3 fatty acids extracted from microalgae on the total antioxidant capacity (TAC) and lipid peroxidation of adipose tissue and plasma from diabetic (db/db) and healthy (CD1) mice.<h4>Methods</h4>Mice were supplemented with lyophilized n-3 fatty acids extracted from microalgae or added to the diet, from week 8 to 16. TAC assay and Thiobarbituric Acid Reactive Substances assay (TBARS) were performed on adipose tissue and plasma samples.<h4>Results</h4>The supplementation of lyophilized n-3 fatty acids from microalgae increased the total antioxidant capacity in adipose tissue of diabetic mice (615.67μM Trolox equivalents vs 405.02μM Trolox equivalents from control mice, p<0.01) and in the plasma of healthy mice (1132.97±85.75μM Trolox equivalents vs 930.64±32μM Trolox equivalents from modified diet mice, p<0.01). There was no significant effect on lipid peroxidation on both strains.<h4>Conclusion</h4>The use of n-3 fatty acids extracted from microalgae could be a useful strategy to improve total antioxidant capacity in T2DM.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2024-11-21T00:40:33.99Z","creation":"2020-11-19T11:31:19Z"},"accession":"S-EPMC7360907","cross_references":{"pubmed":["32053089"],"doi":["10.2174/1871530320666200213111452"]}}