{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Y"],"funding":["National Natural Science Foundation of China"],"pagination":["9478-9482"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7361264"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(16)"],"pubmed_abstract":["Recent retrospective studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) revealed that the patients with common comorbidities of cancers and chronic diseases face significantly poorer clinical outcomes than those without. Since the expression profile of ACE2, a crucial cell entry receptor for SARS-CoV-2, could indicate the susceptibility to SARS-CoV-2 infection, here we systematically dissected ACE2 expression using large-scale multi-omics data from 30 organs/tissues, 33 cancer types and some common chronic diseases involving >28 000 samples. It was found that sex and age could be correlated with the susceptibility of SARS-CoV-2 infection for certain tissues. Strikingly, ACE2 was up-regulated in cervical squamous cell carcinoma and endocervical adenoc"],"journal":["Journal of cellular and molecular medicine"],"pubmed_title":["Systematic profiling of ACE2 expression in diverse physiological and pathological conditions for COVID-19/SARS-CoV-2."],"pmcid":["PMC7361264"],"funding_grant_id":["81870182","91629103","31771460"],"pubmed_authors":["Li H","Li Y","Ma L","Xu Q","Chen G","Gao J","Wu D"],"additional_accession":[]},"is_claimable":false,"name":"Systematic profiling of ACE2 expression in diverse physiological and pathological conditions for COVID-19/SARS-CoV-2.","description":"Recent retrospective studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) revealed that the patients with common comorbidities of cancers and chronic diseases face significantly poorer clinical outcomes than those without. Since the expression profile of ACE2, a crucial cell entry receptor for SARS-CoV-2, could indicate the susceptibility to SARS-CoV-2 infection, here we systematically dissected ACE2 expression using large-scale multi-omics data from 30 organs/tissues, 33 cancer types and some common chronic diseases involving >28 000 samples. It was found that sex and age could be correlated with the susceptibility of SARS-CoV-2 infection for certain tissues. Strikingly, ACE2 was up-regulated in cervical squamous cell carcinoma and endocervical adenoc","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Aug","modification":"2025-04-22T18:44:23.994Z","creation":"2020-08-17T07:12:33Z"},"accession":"S-EPMC7361264","cross_references":{"pubmed":["32639084"],"doi":["10.1111/jcmm.15607"]}}