biostudies-literatureLi YNational Natural Science Foundation of China9478-9482https://www.ebi.ac.uk/biostudies/studies/S-EPMC7361264biostudies-literatureUnknown24(16)Recent retrospective studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) revealed that the patients with common comorbidities of cancers and chronic diseases face significantly poorer clinical outcomes than those without. Since the expression profile of ACE2, a crucial cell entry receptor for SARS-CoV-2, could indicate the susceptibility to SARS-CoV-2 infection, here we systematically dissected ACE2 expression using large-scale multi-omics data from 30 organs/tissues, 33 cancer types and some common chronic diseases involving >28 000 samples. It was found that sex and age could be correlated with the susceptibility of SARS-CoV-2 infection for certain tissues. Strikingly, ACE2 was up-regulated in cervical squamous cell carcinoma and endocervical adenocJournal of cellular and molecular medicineSystematic profiling of ACE2 expression in diverse physiological and pathological conditions for COVID-19/SARS-CoV-2.PMC7361264818701829162910331771460Li HLi YMa LXu QChen GGao JWu DfalseSystematic profiling of ACE2 expression in diverse physiological and pathological conditions for COVID-19/SARS-CoV-2.Recent retrospective studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) revealed that the patients with common comorbidities of cancers and chronic diseases face significantly poorer clinical outcomes than those without. Since the expression profile of ACE2, a crucial cell entry receptor for SARS-CoV-2, could indicate the susceptibility to SARS-CoV-2 infection, here we systematically dissected ACE2 expression using large-scale multi-omics data from 30 organs/tissues, 33 cancer types and some common chronic diseases involving >28 000 samples. It was found that sex and age could be correlated with the susceptibility of SARS-CoV-2 infection for certain tissues. Strikingly, ACE2 was up-regulated in cervical squamous cell carcinoma and endocervical adenoc2020-01-01T00:00:00Z2020 Aug2025-04-22T18:44:23.994Z2020-08-17T07:12:33ZS-EPMC73612643263908410.1111/jcmm.15607