biostudies-literatureUnknown183(5)Le Cleach L<h4>Background</h4>Acral lesions, mainly chilblains, are the most frequently reported cutaneous lesions associated with COVID-19. In more than 80% of patients tested, nasopharyngeal swabs were negative on reverse transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2 when performed, and serology was generally not performed.<h4>Methods</h4>A national survey was launched on 30 March 2020 by the French Society of Dermatology asking physicians to report cases of skin manifestations in patients with suspected or confirmed COVID-19 by using a standardized questionnaire. We report the results for acral manifestations.<h4>Results</h4>We collected 311 cases of acral manifestations [58.5% women, median age 25.7 years (range 18-39)]. The most frequent clinical presentation (65%) was typical The British journal of dermatology866-874https://www.ebi.ac.uk/biostudies/studies/S-EPMC7361395biostudies-literatureMost chilblains observed during the COVID-19 outbreak occur in patients who are negative for COVID-19 on polymerase chain reaction and serology testing.PMC7361395Fourati SMonfort JBBoulard CLevy Roy AWolkenstein PLe Cleach LLesort CColin ASamimi MBeylot-Barry MDousset LTardieu MAssier HMarco-Bonnet JLombart FFrench Society of DermatologyCambon LSbidian EKostrzewa EBarbarot SBourseau Quetier CCazanave CfalseMost chilblains observed during the COVID-19 outbreak occur in patients who are negative for COVID-19 on polymerase chain reaction and serology testing.<h4>Background</h4>Acral lesions, mainly chilblains, are the most frequently reported cutaneous lesions associated with COVID-19. In more than 80% of patients tested, nasopharyngeal swabs were negative on reverse transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2 when performed, and serology was generally not performed.<h4>Methods</h4>A national survey was launched on 30 March 2020 by the French Society of Dermatology asking physicians to report cases of skin manifestations in patients with suspected or confirmed COVID-19 by using a standardized questionnaire. We report the results for acral manifestations.<h4>Results</h4>We collected 311 cases of acral manifestations [58.5% women, median age 25.7 years (range 18-39)]. The most frequent clinical presentation (65%) was typical 2020-01-01T00:00:00Z2020 Nov2025-05-29T22:25:46.354Z2022-07-19T08:25:51.026ZS-EPMC73613953262827010.1111/bjd.19377