{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["108(5)"],"submitter":["Bun SS"],"pubmed_abstract":["Association between Hydroxychloroquine (HCQ) and Azithromycin (AZT) is under evaluation for patients with lower respiratory tract infection (LRTI) caused by the Severe Acute Respiratory Syndrome (SARS-CoV-2). Both drugs have a known torsadogenic potential, but sparse data are available concerning QT prolongation induced by this association. Our objective was to assess for COVID-19 LRTI variations of QT interval under HCQ/AZT in patients hospitalized, and to compare manual versus automated QT measurements. Before therapy initiation, a baseline 12 lead-ECG was electronically sent to our cardiology department for automated and manual QT analysis (Bazett and Fridericia's correction), repeated 2 days after initiation. According to our institutional protocol (Pasteur University Hospital), HCQ/AZ"],"journal":["Clinical pharmacology and therapeutics"],"pagination":["1090-1097"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7361407"],"repository":["biostudies-literature"],"pubmed_title":["QT Interval Prolongation Under Hydroxychloroquine/Azithromycin Association for Inpatients With SARS-CoV-2 Lower Respiratory Tract Infection."],"pmcid":["PMC7361407"],"pubmed_authors":["Marquette CH","Esnault V","Theodore G","Bun SS","Levraut J","Squara F","Dellamonica J","Baudouy D","Labbaoui M","Taghji P","Doyen D","Ferrari E","Scarlatti D","Sartre B","Courjon J"],"additional_accession":[]},"is_claimable":false,"name":"QT Interval Prolongation Under Hydroxychloroquine/Azithromycin Association for Inpatients With SARS-CoV-2 Lower Respiratory Tract Infection.","description":"Association between Hydroxychloroquine (HCQ) and Azithromycin (AZT) is under evaluation for patients with lower respiratory tract infection (LRTI) caused by the Severe Acute Respiratory Syndrome (SARS-CoV-2). Both drugs have a known torsadogenic potential, but sparse data are available concerning QT prolongation induced by this association. Our objective was to assess for COVID-19 LRTI variations of QT interval under HCQ/AZT in patients hospitalized, and to compare manual versus automated QT measurements. Before therapy initiation, a baseline 12 lead-ECG was electronically sent to our cardiology department for automated and manual QT analysis (Bazett and Fridericia's correction), repeated 2 days after initiation. According to our institutional protocol (Pasteur University Hospital), HCQ/AZ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2025-04-04T09:41:17.192Z","creation":"2025-04-04T09:41:17.192Z"},"accession":"S-EPMC7361407","cross_references":{"pubmed":["32588427"],"doi":["10.1002/cpt.1968"]}}