{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(6)"],"submitter":["Gevrek TN"],"pubmed_abstract":["Multifunctionalizable hydrogel coatings on titanium interfaces are useful in a wide range of biomedical applications utilizing titanium-based materials. In this study, furan-protected maleimide groups containing multi-clickable biocompatible hydrogel layers are fabricated on a titanium surface. Upon thermal treatment, the masked maleimide groups within the hydrogel are converted to thiol-reactive maleimide groups. The thiol-reactive maleimide group allows facile functionalization of these hydrogels through the thiol-maleimide nucleophilic addition and Diels-Alder cycloaddition reactions, under mild conditions. Additionally, the strained alkene unit in the furan-protected maleimide moiety undergoes radical thiol-ene reaction, as well as the inverse-electron-demand Diels-Alder reaction with "],"journal":["Polymers"],"pagination":["E1211"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7362003"],"repository":["biostudies-literature"],"pubmed_title":["Multifunctional and Transformable 'Clickable' Hydrogel Coatings on Titanium Surfaces: From Protein Immobilization to Cellular Attachment."],"pmcid":["PMC7362003"],"pubmed_authors":["Gevrek TN","Degirmenci A","Sanyal A","Sanyal R"],"additional_accession":[]},"is_claimable":false,"name":"Multifunctional and Transformable 'Clickable' Hydrogel Coatings on Titanium Surfaces: From Protein Immobilization to Cellular Attachment.","description":"Multifunctionalizable hydrogel coatings on titanium interfaces are useful in a wide range of biomedical applications utilizing titanium-based materials. In this study, furan-protected maleimide groups containing multi-clickable biocompatible hydrogel layers are fabricated on a titanium surface. Upon thermal treatment, the masked maleimide groups within the hydrogel are converted to thiol-reactive maleimide groups. The thiol-reactive maleimide group allows facile functionalization of these hydrogels through the thiol-maleimide nucleophilic addition and Diels-Alder cycloaddition reactions, under mild conditions. Additionally, the strained alkene unit in the furan-protected maleimide moiety undergoes radical thiol-ene reaction, as well as the inverse-electron-demand Diels-Alder reaction with ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 May","modification":"2025-04-22T19:28:31.856Z","creation":"2025-04-06T02:47:44.778Z"},"accession":"S-EPMC7362003","cross_references":{"pubmed":["32466521"],"doi":["10.3390/polym12061211"]}}