{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li J"],"funding":["China Scholarship Council","European Research Council","Qatar National Research Fund","Hartstichting","National Institute of General Medical Sciences","NIGMS NIH HHS","KWF Kankerbestrijding"],"pagination":["356-360"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7362333"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(7)"],"pubmed_abstract":["Physicochemical property switching of chemical space is of great importance for optimization of compounds, for example, for biological activity. Cyclization is a key method to control 3D and other properties. A two-step approach, which involves a multicomponent reaction followed by cyclization, is reported to achieve the transition from basic moieties to charge neutral cyclic derivatives. A series of multisubstituted oxazolidinones, oxazinanones, and oxazepanones as well as their thio and sulfur derivatives are synthesized from readily available building blocks with mild conditions and high yields. Like a few other methods, MCR and cyclization allow for the collective transformation of a large chemical space into a related one with different properties."],"journal":["ACS combinatorial science"],"pubmed_title":["Scaffolding-Induced Property Modulation of Chemical Space."],"pmcid":["PMC7362333"],"funding_grant_id":["2R01GM097082-05","R01 GM097082","10504","2018B012","NPRP6-065-3-012","665250"],"pubmed_authors":["Ruiz-Moreno AJ","Li J","Domling A","Velasco-Velazquez MA","Kalinowska-Tluscik J","Patil P","Di Lorenzo V","Kurpiewska K"],"additional_accession":[]},"is_claimable":false,"name":"Scaffolding-Induced Property Modulation of Chemical Space.","description":"Physicochemical property switching of chemical space is of great importance for optimization of compounds, for example, for biological activity. Cyclization is a key method to control 3D and other properties. A two-step approach, which involves a multicomponent reaction followed by cyclization, is reported to achieve the transition from basic moieties to charge neutral cyclic derivatives. A series of multisubstituted oxazolidinones, oxazinanones, and oxazepanones as well as their thio and sulfur derivatives are synthesized from readily available building blocks with mild conditions and high yields. Like a few other methods, MCR and cyclization allow for the collective transformation of a large chemical space into a related one with different properties.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2025-04-05T13:44:07.809Z","creation":"2025-04-05T13:44:07.809Z"},"accession":"S-EPMC7362333","cross_references":{"pubmed":["32441919"],"doi":["10.1021/acscombsci.0c00072"]}}