biostudies-literatureLi JChina Scholarship CouncilEuropean Research CouncilQatar National Research FundHartstichtingNational Institute of General Medical SciencesNIGMS NIH HHSKWF Kankerbestrijding356-360https://www.ebi.ac.uk/biostudies/studies/S-EPMC7362333biostudies-literatureUnknown22(7)Physicochemical property switching of chemical space is of great importance for optimization of compounds, for example, for biological activity. Cyclization is a key method to control 3D and other properties. A two-step approach, which involves a multicomponent reaction followed by cyclization, is reported to achieve the transition from basic moieties to charge neutral cyclic derivatives. A series of multisubstituted oxazolidinones, oxazinanones, and oxazepanones as well as their thio and sulfur derivatives are synthesized from readily available building blocks with mild conditions and high yields. Like a few other methods, MCR and cyclization allow for the collective transformation of a large chemical space into a related one with different properties.ACS combinatorial scienceScaffolding-Induced Property Modulation of Chemical Space.PMC73623332R01GM097082-05R01 GM097082105042018B012NPRP6-065-3-012665250Ruiz-Moreno AJLi JDomling AVelasco-Velazquez MAKalinowska-Tluscik JPatil PDi Lorenzo VKurpiewska KfalseScaffolding-Induced Property Modulation of Chemical Space.Physicochemical property switching of chemical space is of great importance for optimization of compounds, for example, for biological activity. Cyclization is a key method to control 3D and other properties. A two-step approach, which involves a multicomponent reaction followed by cyclization, is reported to achieve the transition from basic moieties to charge neutral cyclic derivatives. A series of multisubstituted oxazolidinones, oxazinanones, and oxazepanones as well as their thio and sulfur derivatives are synthesized from readily available building blocks with mild conditions and high yields. Like a few other methods, MCR and cyclization allow for the collective transformation of a large chemical space into a related one with different properties.2020-01-01T00:00:00Z2020 Jul2025-04-05T13:44:07.809Z2025-04-05T13:44:07.809ZS-EPMC73623333244191910.1021/acscombsci.0c00072