biostudies-literatureEbner FVO FoUU, Skånes sjukhus nordvästStig och Ragna Gorthons Stiftelse67https://www.ebi.ac.uk/biostudies/studies/S-EPMC7362652biostudies-literatureUnknown28(1)<h4>Background</h4>Exposure to extreme arterial partial pressures of oxygen (PaO₂) and carbon dioxide (PaCO₂) following the return of spontaneous circulation (ROSC) after out-of-hospital cardiac arrest (OHCA) is common and may affect neurological outcome but results of previous studies are conflicting.<h4>Methods</h4>Exploratory study of the International Cardiac Arrest Registry (INTCAR) 2.0 database, including 2162 OHCA patients with ROSC in 22 intensive care units in North America and Europe. We tested the hypothesis that exposure to extreme PaO₂ or PaCO₂ values within 24 h after OHCA is associated with poor neurological outcome at discharge. Our primary analyses investigated the association between extreme PaO₂ and PaCO₂ Scandinavian journal of trauma, resuscitation and emergency medicineThe association of partial pressures of oxygen and carbon dioxide with neurological outcome after out-of-hospital cardiac arrest: an explorative International Cardiac Arrest Registry 2.0 study.PMC7362652NASeder DBMay TLDupont AEbner FForsberg SSoreide EMcPherson JAUllen SDankiewicz JNielsen NRiker RRFriberg HStammet PCronberg THirsch KHaxhija ZfalseThe association of partial pressures of oxygen and carbon dioxide with neurological outcome after out-of-hospital cardiac arrest: an explorative International Cardiac Arrest Registry 2.0 study.<h4>Background</h4>Exposure to extreme arterial partial pressures of oxygen (PaO₂) and carbon dioxide (PaCO₂) following the return of spontaneous circulation (ROSC) after out-of-hospital cardiac arrest (OHCA) is common and may affect neurological outcome but results of previous studies are conflicting.<h4>Methods</h4>Exploratory study of the International Cardiac Arrest Registry (INTCAR) 2.0 database, including 2162 OHCA patients with ROSC in 22 intensive care units in North America and Europe. We tested the hypothesis that exposure to extreme PaO₂ or PaCO₂ values within 24 h after OHCA is associated with poor neurological outcome at discharge. Our primary analyses investigated the association between extreme PaO₂ and PaCO₂ 2020-01-01T00:00:00Z2020 Jul2026-07-15T23:32:44.27Z2025-04-04T20:16:14.776ZS-EPMC73626523266498910.1186/s13049-020-00760-7