biostudies-literatureUnknown10(2)De Lorenzo A<h4>Introduction</h4>Cardiac complications of COVID-19 are potentially life-threatening. The occurrence of myocardial injury in the context of COVID-19 is multifactorial and has generated increasing interest.<h4>Methods</h4>A systematic review with a meta-analysis of the literature was performed. MEDLINE and EMBASE were searched. Two independent reviewers evaluated the selected manuscripts for the outcome "myocardial injury", defined by troponin elevation above the 99th percentile. The study heterogeneity and risk of bias were evaluated.<h4>Results</h4>Eight studies, with a total of 1,229 patients, were included. The frequency of myocardial injury was 16% (95% CI: 9%-27%). The heterogeneity among the studies was high (93%).<h4>Conclusions</h4>Myocardial injury may occur in patients with COAmerican journal of cardiovascular disease28-33https://www.ebi.ac.uk/biostudies/studies/S-EPMC7364273biostudies-literatureAcute cardiac injury in patients with COVID-19.PMC7364273Rey HCTura BRLamas CCDe Lorenzo AKasal DAfalseAcute cardiac injury in patients with COVID-19.<h4>Introduction</h4>Cardiac complications of COVID-19 are potentially life-threatening. The occurrence of myocardial injury in the context of COVID-19 is multifactorial and has generated increasing interest.<h4>Methods</h4>A systematic review with a meta-analysis of the literature was performed. MEDLINE and EMBASE were searched. Two independent reviewers evaluated the selected manuscripts for the outcome "myocardial injury", defined by troponin elevation above the 99th percentile. The study heterogeneity and risk of bias were evaluated.<h4>Results</h4>Eight studies, with a total of 1,229 patients, were included. The frequency of myocardial injury was 16% (95% CI: 9%-27%). The heterogeneity among the studies was high (93%).<h4>Conclusions</h4>Myocardial injury may occur in patients with CO2020-01-01T00:00:00Z20202025-04-21T17:03:56.069Z2025-04-21T17:03:56.069ZS-EPMC736427332685261