{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(27)"],"submitter":["Lienard P"],"pubmed_abstract":["The process selection and subsequent development of a reliable, scalable synthesis of the anticancer prodrug tirapazamine (SR259075) is described in this paper. Reaction of benzofuroxan with cyanamide in acetonitrile in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene at 20-25 °C afforded, after an acidic workup, the targeted molecule in good yield at a kilogram scale. Notable critical parameters and safety enhancements are defined and successfully implemented to produce three consecutive validation batches in a reproducible manner."],"journal":["ACS omega"],"pagination":["16556-16561"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7364547"],"repository":["biostudies-literature"],"pubmed_title":["Development and Validation of a Kilogram-Scale Synthesis of Tirapazamine."],"pmcid":["PMC7364547"],"pubmed_authors":["Elenbaas S","Lienard P"],"additional_accession":[]},"is_claimable":false,"name":"Development and Validation of a Kilogram-Scale Synthesis of Tirapazamine.","description":"The process selection and subsequent development of a reliable, scalable synthesis of the anticancer prodrug tirapazamine (SR259075) is described in this paper. Reaction of benzofuroxan with cyanamide in acetonitrile in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene at 20-25 °C afforded, after an acidic workup, the targeted molecule in good yield at a kilogram scale. Notable critical parameters and safety enhancements are defined and successfully implemented to produce three consecutive validation batches in a reproducible manner.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2025-04-21T17:00:06.895Z","creation":"2025-04-21T17:00:06.895Z"},"accession":"S-EPMC7364547","cross_references":{"pubmed":["32685820"],"doi":["10.1021/acsomega.0c01250"]}}