{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(27)"],"submitter":["Kargbo RB"],"pubmed_abstract":["A second-generation kilogram-scale synthesis of the psychedelic tryptamine psilocybin has been developed. The synthesis was designed to address several challenges first encountered with the scale-up of previously described literature procedures, which were not optimized for providing consistent yield and purity of products, atom economy, or being run in pilot plant-scale reactors. These challenges were addressed and circumvented with the design of the second-generation route, which featured an optimized cGMP large-scale Speeter-Anthony tryptamine synthesis to the intermediate psilocin with improved in-process control and impurity removal over the three steps. Psilocin was subsequently phosphorylated directly with phosphorous oxychloride for the first time, avoiding a tedious and poor atom "],"journal":["ACS omega"],"pagination":["16959-16966"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7364850"],"repository":["biostudies-literature"],"pubmed_title":["Direct Phosphorylation of Psilocin Enables Optimized cGMP Kilogram-Scale Manufacture of Psilocybin."],"pmcid":["PMC7364850"],"pubmed_authors":["Dagger RE","Tarpley G","Cozzi NV","Kaylo K","Patterson T","Meisenheimer P","Sable J","Walker A","Kargbo RB","Sherwood A","O'Hern K"],"additional_accession":[]},"is_claimable":false,"name":"Direct Phosphorylation of Psilocin Enables Optimized cGMP Kilogram-Scale Manufacture of Psilocybin.","description":"A second-generation kilogram-scale synthesis of the psychedelic tryptamine psilocybin has been developed. The synthesis was designed to address several challenges first encountered with the scale-up of previously described literature procedures, which were not optimized for providing consistent yield and purity of products, atom economy, or being run in pilot plant-scale reactors. These challenges were addressed and circumvented with the design of the second-generation route, which featured an optimized cGMP large-scale Speeter-Anthony tryptamine synthesis to the intermediate psilocin with improved in-process control and impurity removal over the three steps. Psilocin was subsequently phosphorylated directly with phosphorous oxychloride for the first time, avoiding a tedious and poor atom ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2025-04-21T17:07:03.663Z","creation":"2025-04-21T17:07:03.663Z"},"accession":"S-EPMC7364850","cross_references":{"pubmed":["32685866"],"doi":["10.1021/acsomega.0c02387"]}}