{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ruz JJ"],"funding":["European Research Council"],"pagination":["6051"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7365328"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4"],"pubmed_abstract":["There is an emerging need of nanotools able to quantify the mechanical properties of single biological entities. A promising approach is the measurement of the shifts of the resonant frequencies of ultrathin cantilevers induced by the adsorption of the studied biological systems. Here, we present a detailed theoretical analysis to calculate the resonance frequency shift induced by the mechanical stiffness of viral nanotubes. The model accounts for the high surface-to-volume ratio featured by single biological entities, the shape anisotropy and the interfacial adhesion. The model is applied to the case in which tobacco mosaic virus is randomly delivered to a silicon nitride cantilever. The theoretical framework opens the door to a novel paradigm for biological spectrometry as well as for measuring the Young's modulus of biological systems with minimal strains."],"journal":["Scientific reports"],"pubmed_title":["Physics of nanomechanical spectrometry of viruses."],"pmcid":["PMC7365328"],"funding_grant_id":["278860"],"pubmed_authors":["Calleja M","Pini V","Kosaka PM","Ruz JJ","Tamayo J"],"additional_accession":[]},"is_claimable":false,"name":"Physics of nanomechanical spectrometry of viruses.","description":"There is an emerging need of nanotools able to quantify the mechanical properties of single biological entities. A promising approach is the measurement of the shifts of the resonant frequencies of ultrathin cantilevers induced by the adsorption of the studied biological systems. Here, we present a detailed theoretical analysis to calculate the resonance frequency shift induced by the mechanical stiffness of viral nanotubes. The model accounts for the high surface-to-volume ratio featured by single biological entities, the shape anisotropy and the interfacial adhesion. The model is applied to the case in which tobacco mosaic virus is randomly delivered to a silicon nitride cantilever. The theoretical framework opens the door to a novel paradigm for biological spectrometry as well as for measuring the Young's modulus of biological systems with minimal strains.","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Aug","modification":"2025-05-29T19:54:50.723Z","creation":"2024-11-06T11:27:46.007Z"},"accession":"S-EPMC7365328","cross_references":{"pubmed":["25116478"],"doi":["10.1038/srep06051"]}}