{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Khang MK"],"funding":["National Heart, Lung and Blood Institute","NHLBI NIH HHS"],"pagination":["1102-1112"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7365982"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(4)"],"pubmed_abstract":["This work details a newly developed \"sandwich\" nanoplatform via neutravidin-biotin system for the detection and treatment of inflammation. First, biotinylated- and folate-conjugated optical imaging micelles targeted activated macrophages via folate/folate receptor interactions. Second, multivalent neutravidin proteins in an optimal concentration accumulated on the biotinylated macrophages. Finally, biotinylated anti-inflammatory drug-loaded micelles delivered drugs effectively at the inflammatory sites via a highly specific neutravidin-biotin affinity. Both <i>in vitro</i> and <i>in vivo</i> studies have shown that the \"sandwich\" pretargeting platform was able to diagnose inflammation by targeting activated macrophages as well as improve the therapeutic efficacy by amplifying the drug deli"],"journal":["Bioactive materials"],"pubmed_title":["A pretargeting nanoplatform for imaging and enhancing anti-inflammatory drug delivery."],"pmcid":["PMC7365982"],"funding_grant_id":["T32 HL134613","NIH T32 HL134613"],"pubmed_authors":["Khang MK","Tang L","Li S","Co CM","Zhou J"],"additional_accession":[]},"is_claimable":false,"name":"A pretargeting nanoplatform for imaging and enhancing anti-inflammatory drug delivery.","description":"This work details a newly developed \"sandwich\" nanoplatform via neutravidin-biotin system for the detection and treatment of inflammation. First, biotinylated- and folate-conjugated optical imaging micelles targeted activated macrophages via folate/folate receptor interactions. Second, multivalent neutravidin proteins in an optimal concentration accumulated on the biotinylated macrophages. Finally, biotinylated anti-inflammatory drug-loaded micelles delivered drugs effectively at the inflammatory sites via a highly specific neutravidin-biotin affinity. Both <i>in vitro</i> and <i>in vivo</i> studies have shown that the \"sandwich\" pretargeting platform was able to diagnose inflammation by targeting activated macrophages as well as improve the therapeutic efficacy by amplifying the drug deli","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2025-04-04T13:38:26.814Z","creation":"2025-04-04T13:38:26.814Z"},"accession":"S-EPMC7365982","cross_references":{"pubmed":["32695939"],"doi":["10.1016/j.bioactmat.2020.06.019"]}}