{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu KC"],"funding":["National Center for Advancing Translational Sciences","National Institute of Allergy and Infectious Diseases","NCATS NIH HHS","NIAID NIH HHS","NHLBI NIH HHS","National Heart, Lung, and Blood Institute"],"pagination":["559-565"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7366367"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["105(7)"],"pubmed_abstract":["<h4>Objective</h4>HIV-infected (HIV+) individuals may be at increased risk for sudden arrhythmic cardiac death. Some studies have reported an association between HIV infection and prolongation of the electrocardiographic QT interval, a measure of ventricular repolarisation, which could potentiate ventricular arrhythmias. We aimed to assess whether HIV+ men have longer QT intervals than HIV-uninfected (HIV-) men and to determine factors associated with QT duration.<h4>Methods</h4>We performed resting 12-lead ECGs in 774 HIV+ and 652 HIV- men in the Multicenter AIDS Cohort Study (MACS). We used multivariable linear and logistic regression analyses to assess associations between HIV serostatus and Framingham corrected QT interval (QTc), after accounting for potential confounders. We also determined associations among QTc interval and HIV-related factors in HIV+ men. In a subgroup of participants, levels of serum markers of inflammation were also assessed.<h4>Results</h4>After adjusting for demographics and risk factors, QTc was 4.0 ms longer in HIV+ than HIV- men (p<0.001). Use of antiretroviral therapy (ART), specific ART drug class use and other HIV-specific risk factors were not associated with longer QTc. Among the subgroup with inflammatory biomarker measurements, higher interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1) and B-cell activating factor levels were independently associated with longer QTc and their inclusion partially attenuated the HIV effect.<h4>Conclusions</h4>HIV+ men had longer QTc, which was associated with higher levels of systemic inflammatory factors. This longer QTc may contribute to the increased risk for sudden arrhythmic cardiac death in some HIV+ individuals."],"journal":["Heart (British Cardiac Society)"],"pubmed_title":["Predictors of electrocardiographic QT interval prolongation in men with HIV."],"pmcid":["PMC7366367"],"funding_grant_id":["U01 AI035041","U01 AI035040","UL1 TR001079","UM1 AI035043","R01 HL095129","U01 AI035039","U01 HL146193"],"pubmed_authors":["Ashikaga H","Wu KC","Margolick JB","Soliman EZ","Zhang L","Budoff MJ","Haberlen SA","Kingsley LA","D'Souza G","Palella FJ","Brown TT","Post WS","Martinez-Maza O"],"additional_accession":[]},"is_claimable":false,"name":"Predictors of electrocardiographic QT interval prolongation in men with HIV.","description":"<h4>Objective</h4>HIV-infected (HIV+) individuals may be at increased risk for sudden arrhythmic cardiac death. Some studies have reported an association between HIV infection and prolongation of the electrocardiographic QT interval, a measure of ventricular repolarisation, which could potentiate ventricular arrhythmias. We aimed to assess whether HIV+ men have longer QT intervals than HIV-uninfected (HIV-) men and to determine factors associated with QT duration.<h4>Methods</h4>We performed resting 12-lead ECGs in 774 HIV+ and 652 HIV- men in the Multicenter AIDS Cohort Study (MACS). We used multivariable linear and logistic regression analyses to assess associations between HIV serostatus and Framingham corrected QT interval (QTc), after accounting for potential confounders. We also determined associations among QTc interval and HIV-related factors in HIV+ men. In a subgroup of participants, levels of serum markers of inflammation were also assessed.<h4>Results</h4>After adjusting for demographics and risk factors, QTc was 4.0 ms longer in HIV+ than HIV- men (p<0.001). Use of antiretroviral therapy (ART), specific ART drug class use and other HIV-specific risk factors were not associated with longer QTc. Among the subgroup with inflammatory biomarker measurements, higher interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1) and B-cell activating factor levels were independently associated with longer QTc and their inclusion partially attenuated the HIV effect.<h4>Conclusions</h4>HIV+ men had longer QTc, which was associated with higher levels of systemic inflammatory factors. This longer QTc may contribute to the increased risk for sudden arrhythmic cardiac death in some HIV+ individuals.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Apr","modification":"2025-04-05T13:48:22.894Z","creation":"2025-04-05T13:48:22.894Z"},"accession":"S-EPMC7366367","cross_references":{"pubmed":["30366934"],"doi":["10.1136/heartjnl-2018-313667"]}}