{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vandehoef C"],"funding":["NIDDK NIH HHS","NIH HHS"],"pagination":["107736"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7366522"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(10)"],"pubmed_abstract":["Dietary nutrients shape complex interactions between hosts and their commensal gut bacteria, further promoting flexibility in host-microbiota associations that can drive nutritional symbiosis. However, it remains less clear if diet-dependent host signaling mechanisms also influence these associations. Using Drosophila, we show here that nuclear factor ?B (NF-?B)/Relish, an innate immune transcription factor emerging as a signaling node linking nutrient-immune-metabolic interactions, is vital to adapt gut microbiota species composition to host diet macronutrient composition. We find that Relish is required within midgut enterocytes to amplify host-Lactobacillus associations, an important bacterial mediator of nutritional symbiosis, and thus modulate microbiota composition in response to dietary adaptation. Relish limits diet-dependent transcriptional inducibility of the cap-dependent translation inhibitor 4E-BP/Thor to control microbiota composition. Furthermore, maintaining cap-dependent translation in response to dietary adaptation is critical to amplify host-Lactobacillus associations. These results highlight that NF-?B-dependent host signaling mechanisms, in coordination with host translation control, shape diet-microbiota interactions."],"journal":["Cell reports"],"pubmed_title":["Dietary Adaptation of Microbiota in Drosophila Requires NF-?B-Dependent Control of the Translational Regulator 4E-BP."],"pmcid":["PMC7366522"],"funding_grant_id":["R01 DK108930","F30 DK117538","P40 OD010949"],"pubmed_authors":["Vandehoef C","Karpac J","Molaei M"],"additional_accession":[]},"is_claimable":false,"name":"Dietary Adaptation of Microbiota in Drosophila Requires NF-?B-Dependent Control of the Translational Regulator 4E-BP.","description":"Dietary nutrients shape complex interactions between hosts and their commensal gut bacteria, further promoting flexibility in host-microbiota associations that can drive nutritional symbiosis. However, it remains less clear if diet-dependent host signaling mechanisms also influence these associations. Using Drosophila, we show here that nuclear factor ?B (NF-?B)/Relish, an innate immune transcription factor emerging as a signaling node linking nutrient-immune-metabolic interactions, is vital to adapt gut microbiota species composition to host diet macronutrient composition. We find that Relish is required within midgut enterocytes to amplify host-Lactobacillus associations, an important bacterial mediator of nutritional symbiosis, and thus modulate microbiota composition in response to dietary adaptation. Relish limits diet-dependent transcriptional inducibility of the cap-dependent translation inhibitor 4E-BP/Thor to control microbiota composition. Furthermore, maintaining cap-dependent translation in response to dietary adaptation is critical to amplify host-Lactobacillus associations. These results highlight that NF-?B-dependent host signaling mechanisms, in coordination with host translation control, shape diet-microbiota interactions.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2020-09-18T07:05:47Z","creation":"2020-09-11T07:10:01Z"},"accession":"S-EPMC7366522","cross_references":{"pubmed":["32521261"],"doi":["10.1016/j.celrep.2020.107736"]}}