{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jin D"],"funding":["National Natural Science Foundation of China","China Postdoctoral Science Foundation","Sichuan University"],"pagination":["4897-4906"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7367637"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(14)"],"pubmed_abstract":["<h4>Purpose</h4>To study prognostic values of the clinicopathological characteristics and survival outcomes in micropapillary urothelial carcinoma (MPUC) of the urinary bladder.<h4>Method</h4>We used the national Surveillance, Epidemiology, and End Results database (2004-2016) to compare MPUC with transitional cell carcinoma (TCC) and to investigate prognostic values of clinicopathological characteristics, as well as survival outcomes, in MPUC of the urinary bladder. A multivariable Cox proportional hazard model, subgroup analyses, and propensity score matching were used.<h4>Results</h4>In all, 519 patients with MPUC and 154 453 patients with TCC were enrolled. Compared with TCC, patients with MPUC had a higher rate of muscle invasive disease (P < .001), lymph node metastasis (P < .001), and distal metastasis (P < .001), as well as higher tumor grade (P < .001). According to the survival analyses, the MPUC group also had lower survival probability in both cancer-specific mortality (CSM) (P < .0001) and overall mortality (OM) analyses (P < .0001). Cox proportional hazard regression showed that the MPUC group had a higher risk of OM (hazard ratios [HR] = 1.39, 95% confidence intervals [CI] = 1.22-1.57, P < .0001), although the CSM (HR = 1.18, 95% CI = 1.00-1.40, P = .0505) in that group was fair. In the subgroup analysis, only MPUC patients without distal metastasis faced a higher risk of CSM (HR = 1.33, 95% CI = 1.101.61, P < .0001).<h4>Conclusions</h4>Micropapillary urothelial carcinoma prognosis is poorer than that of TCC. Micropapillary urothelial carcinoma is an independent prognostic factor for OM in patients with urinary bladder cancer."],"journal":["Cancer medicine"],"pubmed_title":["Prognostic values of the clinicopathological characteristics and survival outcomes in micropapillary urothelial carcinoma of the bladder: A SEER database analysis."],"pmcid":["PMC7367637"],"funding_grant_id":["Z2018C01","81974098","81902578","2018HXBH085","2017M612971"],"pubmed_authors":["Yang L","Wei Q","Qiu S","Jin D","Yuan Q","Zhou X","Jin K"],"additional_accession":[]},"is_claimable":false,"name":"Prognostic values of the clinicopathological characteristics and survival outcomes in micropapillary urothelial carcinoma of the bladder: A SEER database analysis.","description":"<h4>Purpose</h4>To study prognostic values of the clinicopathological characteristics and survival outcomes in micropapillary urothelial carcinoma (MPUC) of the urinary bladder.<h4>Method</h4>We used the national Surveillance, Epidemiology, and End Results database (2004-2016) to compare MPUC with transitional cell carcinoma (TCC) and to investigate prognostic values of clinicopathological characteristics, as well as survival outcomes, in MPUC of the urinary bladder. A multivariable Cox proportional hazard model, subgroup analyses, and propensity score matching were used.<h4>Results</h4>In all, 519 patients with MPUC and 154 453 patients with TCC were enrolled. Compared with TCC, patients with MPUC had a higher rate of muscle invasive disease (P < .001), lymph node metastasis (P < .001), and distal metastasis (P < .001), as well as higher tumor grade (P < .001). According to the survival analyses, the MPUC group also had lower survival probability in both cancer-specific mortality (CSM) (P < .0001) and overall mortality (OM) analyses (P < .0001). Cox proportional hazard regression showed that the MPUC group had a higher risk of OM (hazard ratios [HR] = 1.39, 95% confidence intervals [CI] = 1.22-1.57, P < .0001), although the CSM (HR = 1.18, 95% CI = 1.00-1.40, P = .0505) in that group was fair. In the subgroup analysis, only MPUC patients without distal metastasis faced a higher risk of CSM (HR = 1.33, 95% CI = 1.101.61, P < .0001).<h4>Conclusions</h4>Micropapillary urothelial carcinoma prognosis is poorer than that of TCC. Micropapillary urothelial carcinoma is an independent prognostic factor for OM in patients with urinary bladder cancer.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2025-04-06T19:39:51.724Z","creation":"2025-04-06T19:39:51.724Z"},"accession":"S-EPMC7367637","cross_references":{"pubmed":["32529761"],"doi":["10.1002/cam4.3147"]}}