{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim TM"],"funding":["National Research Foundation of Korea"],"pagination":["3616"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7367841"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["Genomic and precision medicine research has afforded notable advances in human cancer treatment, yet applicability to other species remains uncertain. Through whole-exome and transcriptome analyses of 191 spontaneous canine mammary tumors (CMTs) that exhibit the archetypal features of human breast cancers, we found a striking resemblance of genomic characteristics including frequent PIK3CA mutations (43.1%), aberrations of the PI3K-Akt pathway (61.7%), and key genes involved in cancer initiation and progression. We also identified three gene expression-based CMT subtypes, one of which segregated with basal-like human breast cancer subtypes with activated epithelial-to-mesenchymal transition, low claudin expression, and unfavorable disease prognosis. A relative lack of ERBB2 amplification a"],"journal":["Nature communications"],"pubmed_title":["Cross-species oncogenic signatures of breast cancer in canine mammary tumors."],"pmcid":["PMC7367841"],"funding_grant_id":["2016M3A9B6903439","2019R1A2C2002315"],"pubmed_authors":["Lee S","Kim D","Kim KK","Seo MK","Yang IS","Kim HS","Sur JH","Kim S","Cheong JH","Seung BJ","Nam H","Ha YJ","Kim TM"],"additional_accession":[]},"is_claimable":false,"name":"Cross-species oncogenic signatures of breast cancer in canine mammary tumors.","description":"Genomic and precision medicine research has afforded notable advances in human cancer treatment, yet applicability to other species remains uncertain. Through whole-exome and transcriptome analyses of 191 spontaneous canine mammary tumors (CMTs) that exhibit the archetypal features of human breast cancers, we found a striking resemblance of genomic characteristics including frequent PIK3CA mutations (43.1%), aberrations of the PI3K-Akt pathway (61.7%), and key genes involved in cancer initiation and progression. We also identified three gene expression-based CMT subtypes, one of which segregated with basal-like human breast cancer subtypes with activated epithelial-to-mesenchymal transition, low claudin expression, and unfavorable disease prognosis. A relative lack of ERBB2 amplification a","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2026-07-15T23:34:47.487Z","creation":"2025-04-19T18:02:15.896Z"},"accession":"S-EPMC7367841","cross_references":{"pubmed":["32680987"],"doi":["10.1038/s41467-020-17458-0"]}}