biostudies-literatureKim TMNational Research Foundation of Korea3616https://www.ebi.ac.uk/biostudies/studies/S-EPMC7367841biostudies-literatureUnknown11(1)Genomic and precision medicine research has afforded notable advances in human cancer treatment, yet applicability to other species remains uncertain. Through whole-exome and transcriptome analyses of 191 spontaneous canine mammary tumors (CMTs) that exhibit the archetypal features of human breast cancers, we found a striking resemblance of genomic characteristics including frequent PIK3CA mutations (43.1%), aberrations of the PI3K-Akt pathway (61.7%), and key genes involved in cancer initiation and progression. We also identified three gene expression-based CMT subtypes, one of which segregated with basal-like human breast cancer subtypes with activated epithelial-to-mesenchymal transition, low claudin expression, and unfavorable disease prognosis. A relative lack of ERBB2 amplification aNature communicationsCross-species oncogenic signatures of breast cancer in canine mammary tumors.PMC73678412016M3A9B69034392019R1A2C2002315Lee SKim DKim KKSeo MKYang ISKim HSSur JHKim SCheong JHSeung BJNam HHa YJKim TMfalseCross-species oncogenic signatures of breast cancer in canine mammary tumors.Genomic and precision medicine research has afforded notable advances in human cancer treatment, yet applicability to other species remains uncertain. Through whole-exome and transcriptome analyses of 191 spontaneous canine mammary tumors (CMTs) that exhibit the archetypal features of human breast cancers, we found a striking resemblance of genomic characteristics including frequent PIK3CA mutations (43.1%), aberrations of the PI3K-Akt pathway (61.7%), and key genes involved in cancer initiation and progression. We also identified three gene expression-based CMT subtypes, one of which segregated with basal-like human breast cancer subtypes with activated epithelial-to-mesenchymal transition, low claudin expression, and unfavorable disease prognosis. A relative lack of ERBB2 amplification a2020-01-01T00:00:00Z2020 Jul2026-07-15T23:34:47.487Z2025-04-19T18:02:15.896ZS-EPMC73678413268098710.1038/s41467-020-17458-0