biostudies-literatureLee JHCCR NIH HHSNational Institute of Allergy and Infectious DiseasesNIAID NIH HHSNational Cancer InstituteNCI NIH HHSNational Institutes of HealthS419-S430https://www.ebi.ac.uk/biostudies/studies/S-EPMC7368178biostudies-literatureUnknown221(Suppl 4)Nipah virus (NiV) is an emerging virus associated with outbreaks of acute respiratory disease and encephalitis. To develop a neurological model for NiV infection, we exposed 6 adult African green monkeys to a large-particle (approximately 12 μm) aerosol containing NiV (Malaysian isolate). Brain magnetic resonance images were obtained at baseline, every 3 days after exposure for 2 weeks, and then weekly until week 8 after exposure. Four of six animals showed abnormalities reminiscent of human disease in brain magnetic resonance images. Abnormalities ranged from cytotoxic edema to vasogenic edema. The majority of lesions were small infarcts, and a few showed inflammatory or encephalitic changes. Resolution or decreased size in some lesions resembled findings reported in patients with NiV infThe Journal of infectious diseasesThe Use of Large-Particle Aerosol Exposure to Nipah Virus to Mimic Human Neurological Disease Manifestations in the African Green Monkey.PMC7368178HHSN261200800001EHHSN261200800001CHHSN272200700016IBohannon JKRojas OHuzella LMLackemeyer MSolomon JCastro MAMunster VRagland DAdams RHolbrook MRByrum RCong YLaux JHammoud DASt Claire MLee JHfalseThe Use of Large-Particle Aerosol Exposure to Nipah Virus to Mimic Human Neurological Disease Manifestations in the African Green Monkey.Nipah virus (NiV) is an emerging virus associated with outbreaks of acute respiratory disease and encephalitis. To develop a neurological model for NiV infection, we exposed 6 adult African green monkeys to a large-particle (approximately 12 μm) aerosol containing NiV (Malaysian isolate). Brain magnetic resonance images were obtained at baseline, every 3 days after exposure for 2 weeks, and then weekly until week 8 after exposure. Four of six animals showed abnormalities reminiscent of human disease in brain magnetic resonance images. Abnormalities ranged from cytotoxic edema to vasogenic edema. The majority of lesions were small infarcts, and a few showed inflammatory or encephalitic changes. Resolution or decreased size in some lesions resembled findings reported in patients with NiV inf2020-01-01T00:00:00Z2020 May2026-04-07T21:24:22.285Z2025-04-03T21:31:15.408ZS-EPMC73681783168775610.1093/infdis/jiz502