{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Z"],"funding":["National Natural Science Foundation of China"],"pagination":["9827349"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7368952"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2020"],"pubmed_abstract":["<h4>Background</h4>Some studies have demonstrated that inflammation is highly associated with the prevalence of thyroid nodules (TNs). However, more confounders, such as metabolic diseases, should be adjusted.<h4>Methods</h4>A clinical study collecting 2722 subjects was conducted to confirm the association between inflammation and TNs. The underlying mechanism was investigated in combination with bioinformatics analysis.<h4>Results</h4>In the clinical study, propensity score matching was used to match metabolic parameters and other confounders, and it is observed that subjects with high inflammation had a higher prevalence of TNs and thyroid-stimulating hormone (TSH) than those with low inflammation. After further matching TNs, it is found that inflammation was positively associated with T"],"journal":["International journal of endocrinology"],"pubmed_title":["The Effect of Inflammation on the Formation of Thyroid Nodules."],"pmcid":["PMC7368952"],"funding_grant_id":["81370925","S2012010009336","2020A1515011100","B2019182","2013B021800254","81373745","10151503102000017","81172894"],"pubmed_authors":["Li Z","Huang Y","Wei C","Yang P","Chen X","Xu W"],"additional_accession":[]},"is_claimable":false,"name":"The Effect of Inflammation on the Formation of Thyroid Nodules.","description":"<h4>Background</h4>Some studies have demonstrated that inflammation is highly associated with the prevalence of thyroid nodules (TNs). However, more confounders, such as metabolic diseases, should be adjusted.<h4>Methods</h4>A clinical study collecting 2722 subjects was conducted to confirm the association between inflammation and TNs. The underlying mechanism was investigated in combination with bioinformatics analysis.<h4>Results</h4>In the clinical study, propensity score matching was used to match metabolic parameters and other confounders, and it is observed that subjects with high inflammation had a higher prevalence of TNs and thyroid-stimulating hormone (TSH) than those with low inflammation. After further matching TNs, it is found that inflammation was positively associated with T","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2026-04-29T08:40:18.264Z","creation":"2020-07-31T09:18:10Z"},"accession":"S-EPMC7368952","cross_references":{"pubmed":["32695162"],"doi":["10.1155/2020/9827349"]}}