{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Balhorn R"],"funding":["Deutsche Forschungsgemeinschaft"],"pagination":["E4679"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7370281"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(13)"],"pubmed_abstract":["Hypertensive patients have an increased risk of developing chronic kidney disease (CKD). Many of these patients have increased levels of the blood pressure regulating mineralocorticoid aldosterone. As a protection against aldosterone-induced damage, kidney cells can upregulate key regulators of the antioxidant defense, such as nuclear factor-erythroid-2-related factor 2 (Nrf2). In the present study aldosterone-induced kidney damage and Nrf2 activation in kidney cells of mice treated with three different concentrations of aldosterone for 4 weeks was localized. Increased albumin and neutrophil gelatinase-associated lipocalin (NGAL) in urine revealed an impaired kidney function of the aldosterone-infused mice. Localization of aldosterone-induced oxidative damage (in the form of DNA lesions) i"],"journal":["International journal of molecular sciences"],"pubmed_title":["Aldosterone Induces DNA Damage and Activation of Nrf2 Mainly in Tubuli of Mouse Kidneys."],"pmcid":["PMC7370281"],"funding_grant_id":["Schu 2367/5-4"],"pubmed_authors":["Balhorn R","Hartmann C","Schupp N"],"additional_accession":[]},"is_claimable":false,"name":"Aldosterone Induces DNA Damage and Activation of Nrf2 Mainly in Tubuli of Mouse Kidneys.","description":"Hypertensive patients have an increased risk of developing chronic kidney disease (CKD). Many of these patients have increased levels of the blood pressure regulating mineralocorticoid aldosterone. As a protection against aldosterone-induced damage, kidney cells can upregulate key regulators of the antioxidant defense, such as nuclear factor-erythroid-2-related factor 2 (Nrf2). In the present study aldosterone-induced kidney damage and Nrf2 activation in kidney cells of mice treated with three different concentrations of aldosterone for 4 weeks was localized. Increased albumin and neutrophil gelatinase-associated lipocalin (NGAL) in urine revealed an impaired kidney function of the aldosterone-infused mice. Localization of aldosterone-induced oxidative damage (in the form of DNA lesions) i","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2025-04-05T08:45:13.777Z","creation":"2025-04-05T08:45:13.777Z"},"accession":"S-EPMC7370281","cross_references":{"pubmed":["32630085"],"doi":["10.3390/ijms21134679"]}}