biostudies-literature00420Unknown40(2)Polinder-Bos HANear-infrared spectroscopy (NIRS) is used to monitor cerebral tissue oxygenation (rSO₂) depending on cerebral blood flow (CBF), cerebral blood volume and blood oxygen content. We explored whether NIRS might be a more easy applicable proxy to [¹⁵O]H₂O positron emission tomography (PET) for detecting CBF changes during hemodialysis. Furthermore, we compared potential determinants of rSO₂ and CBF. In 12 patients aged ≥ 65 years, NIRS and PET were performed simultaneously: before (T1), early after start (T2), and at the end of hemodialysis (T3). Between T1 and T3, the relative change in frontal rSO₂ (ΔrSO₂) was -8 ± 9% (<i>P</i> = 0.001) and -5 ± 11% (<i>P</i> = 0.08), whereas the relative change in frontal gray matter CBF (ΔCBF) was -11 ± 18% (<i>P</i> = 0.009) and -12 ± 16% (<i>P</i> = 0.007) for the left and right hemisphere, respectively. ΔrSO₂ and ΔCBF were weakly correlated for the left (ρ 0.31, <i>P</i> = 0.4), and moderately correlated for the right (ρ 0.69, <i>P</i> = 0.03) hemisphere. The Bland-Altman plot suggested underestimation of ΔCBF by NIRS. Divergent associations of pH, pCO₂ and arterial oxygen content with rSO₂ were found compared to corresponding associations with CBF. In conclusion, NIRS could be a proxy to PET to detect intradialytic CBF changes, although NIRS and PET capture different physiological parameters of the brain.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism328-340https://www.ebi.ac.uk/biostudies/studies/S-EPMC7370620biostudies-literatureChanges in cerebral oxygenation and cerebral blood flow during hemodialysis - A simultaneous near-infrared spectroscopy and positron emission tomography study.PMC7370620van Laar PJPolinder-Bos HAElting JWJSlart RHKrijnen WPLuurtsema GAries MJWesterhuis RWillemsen ATGaillard CAGarcia DVKuipers JFranssen CFGansevoort RT42falseChanges in cerebral oxygenation and cerebral blood flow during hemodialysis - A simultaneous near-infrared spectroscopy and positron emission tomography study.Near-infrared spectroscopy (NIRS) is used to monitor cerebral tissue oxygenation (rSO₂) depending on cerebral blood flow (CBF), cerebral blood volume and blood oxygen content. We explored whether NIRS might be a more easy applicable proxy to [¹⁵O]H₂O positron emission tomography (PET) for detecting CBF changes during hemodialysis. Furthermore, we compared potential determinants of rSO₂ and CBF. In 12 patients aged ≥ 65 years, NIRS and PET were performed simultaneously: before (T1), early after start (T2), and at the end of hemodialysis (T3). Between T1 and T3, the relative change in frontal rSO₂ (ΔrSO₂) was -8 ± 9% (<i>P</i> = 0.001) and -5 ± 11% (<i>P</i> = 0.08), whereas the relative change in frontal gray matter CBF (ΔCBF) was -11 ± 18% (<i>P</i> = 0.009) and -12 ± 16% (<i>P</i> = 0.007) for the left and right hemisphere, respectively. ΔrSO₂ and ΔCBF were weakly correlated for the left (ρ 0.31, <i>P</i> = 0.4), and moderately correlated for the right (ρ 0.69, <i>P</i> = 0.03) hemisphere. The Bland-Altman plot suggested underestimation of ΔCBF by NIRS. Divergent associations of pH, pCO₂ and arterial oxygen content with rSO₂ were found compared to corresponding associations with CBF. In conclusion, NIRS could be a proxy to PET to detect intradialytic CBF changes, although NIRS and PET capture different physiological parameters of the brain.2020-01-01T00:00:00Z2020 Feb2024-10-19T12:59:13.678Z2021-02-21T05:13:36ZS-EPMC73706203054021910.1177/0271678x1881865210.1177/0271678X18818652