biostudies-literatureBrown SANIDDK NIH HHSNational Institute of Diabetes and Digestive and Kidney Diseases1822-1828https://www.ebi.ac.uk/biostudies/studies/S-EPMC7372060biostudies-literatureUnknown43(8)<h4>Objective</h4>Limited information is available about glycemic outcomes with a closed-loop control (CLC) system compared with a predictive low-glucose suspend (PLGS) system.<h4>Research design and methods</h4>After 6 months of use of a CLC system in a randomized trial, 109 participants with type 1 diabetes (age range, 14-72 years; mean HbA_1c, 7.1% [54 mmol/mol]) were randomly assigned to CLC (<i>N</i> = 54, Control-IQ) or PLGS (<i>N</i> = 55, Basal-IQ) groups for 3 months. The primary outcome was continuous glucose monitor (CGM)-measured time in range (TIR) for 70-180 mg/dL. Baseline CGM metrics were computed from the last 3 months of the preceding study.<h4>Results</h4>All 109 participants completed the study. Mean ± SD TIR was 71.1 ± 11.2% at baseline and 67.6 ± 12.6% usingDiabetes careGlycemic Outcomes of Use of CLC Versus PLGS in Type 1 Diabetes: A Randomized Controlled Trial.PMC7372060P30 DK036836UC4 DK108483UC4 108483McCrady-Spitzer SWilli SMLevy CJPatibandla NEggerman TSlover RLaffel LMAnderson SMDadlani VIsganaitis EForlenza GFlint ETabatabai IBeck RBeck RWCalvo KSimha VBrown SALegault LAmbler-Osborn LLevister CRenard EKeller JBerget CPinsker JEAndre CMurphy CKollman CCampos TiDCL Trial Research GroupEmory EJost EJacobson TGabrielson DBreton MDConshafter KKovatchev BO'Malley GCastle JLam DDoyle Iii FKudva YCReznik YAnderson SKim KLevy CRossick-Solis ARaghinaru DBorgman SKovatchev BPLaffel LPinsker JEkhlaspour LMorris KDassau ELum JWWysham CTowers LBelle SHChurch MMSalas EVoelmle MMesser LDoyle FBuckingham BADoyle FJMitchell HRoethke LPiper MAlonso GTBuckingham BLum JWakeman CGreen JBreton MOgyaadu SPassman SGreen NForlenza GPCobelli CLovett JOliveri MGondor-Fredrick LTown MArreza-Rubin GWadwa RPReid CKumari KBrown SJanicek RfalseGlycemic Outcomes of Use of CLC Versus PLGS in Type 1 Diabetes: A Randomized Controlled Trial.<h4>Objective</h4>Limited information is available about glycemic outcomes with a closed-loop control (CLC) system compared with a predictive low-glucose suspend (PLGS) system.<h4>Research design and methods</h4>After 6 months of use of a CLC system in a randomized trial, 109 participants with type 1 diabetes (age range, 14-72 years; mean HbA_1c, 7.1% [54 mmol/mol]) were randomly assigned to CLC (<i>N</i> = 54, Control-IQ) or PLGS (<i>N</i> = 55, Basal-IQ) groups for 3 months. The primary outcome was continuous glucose monitor (CGM)-measured time in range (TIR) for 70-180 mg/dL. Baseline CGM metrics were computed from the last 3 months of the preceding study.<h4>Results</h4>All 109 participants completed the study. Mean ± SD TIR was 71.1 ± 11.2% at baseline and 67.6 ± 12.6% using2020-01-01T00:00:00Z2020 Aug2025-05-29T20:48:18.583Z2022-02-11T02:08:12.753ZS-EPMC73720603247191010.2337/dc20-0124