{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim H"],"funding":["Yeungnam University"],"pagination":["e21060"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7373553"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["99(29)"],"pubmed_abstract":["<h4>Background</h4>Postoperative sore throat (POST) is an important concern in surgical patients undergoing endotracheal intubation. Its prevalence after thyroidectomy is up to 80%. The current study aimed to assess the effect of dexmedetomidine and remifentanil on postoperative sore throat.<h4>Methods</h4>Seventy-four patients who underwent thyroidectomy were randomized to receive either dexmedetomidine (group D) or remifentanil (group R). At anesthesia induction, group D received dexmedetomidine 1 μg/kg over 10 minutes, followed by continuous dexmedetomidine infusion at 0.3 to 0.6 μg/kg/hour during surgery. Group R received remifentanil of 3 to 4 ng/ml during induction, followed by 1.5 to 2.5 ng/ml remifentanil infusion during surgery. POST at rest and swallowing was assessed during the first 24 hours in serial time periods (0-1, 1-6, and 6-24 hours). Hoarseness and postoperative pain score were also assessed.<h4>Results</h4>POST incidence at rest (0-1, 1-6, and 6-24 hours) and swallowing (1-6 and 6-24 hours) was lower in group D than in group R. POST severity was significantly lower in group D than in group R during each time period. The incidence of postoperative hoarseness was also lower in group D than in group R at 1 to 6 and 6 to 24 hours. The postoperative pain score was lower in group D than in group R during each time period.<h4>Conclusion</h4>Intraoperative dexmedetomidine infusion reduced the incidence and severity of POST for 24 hours after thyroidectomy."],"journal":["Medicine"],"pubmed_title":["The effect of dexmedetomidine and remifentanil on the postoperative sore throat after thyroidectomy."],"pmcid":["PMC7373553"],"funding_grant_id":["2018 Yeungnam University Research Grant"],"pubmed_authors":["Choi EK","Jeon S","Kim H","Kwon H"],"additional_accession":[]},"is_claimable":false,"name":"The effect of dexmedetomidine and remifentanil on the postoperative sore throat after thyroidectomy.","description":"<h4>Background</h4>Postoperative sore throat (POST) is an important concern in surgical patients undergoing endotracheal intubation. Its prevalence after thyroidectomy is up to 80%. The current study aimed to assess the effect of dexmedetomidine and remifentanil on postoperative sore throat.<h4>Methods</h4>Seventy-four patients who underwent thyroidectomy were randomized to receive either dexmedetomidine (group D) or remifentanil (group R). At anesthesia induction, group D received dexmedetomidine 1 μg/kg over 10 minutes, followed by continuous dexmedetomidine infusion at 0.3 to 0.6 μg/kg/hour during surgery. Group R received remifentanil of 3 to 4 ng/ml during induction, followed by 1.5 to 2.5 ng/ml remifentanil infusion during surgery. POST at rest and swallowing was assessed during the first 24 hours in serial time periods (0-1, 1-6, and 6-24 hours). Hoarseness and postoperative pain score were also assessed.<h4>Results</h4>POST incidence at rest (0-1, 1-6, and 6-24 hours) and swallowing (1-6 and 6-24 hours) was lower in group D than in group R. POST severity was significantly lower in group D than in group R during each time period. The incidence of postoperative hoarseness was also lower in group D than in group R at 1 to 6 and 6 to 24 hours. The postoperative pain score was lower in group D than in group R during each time period.<h4>Conclusion</h4>Intraoperative dexmedetomidine infusion reduced the incidence and severity of POST for 24 hours after thyroidectomy.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2025-04-18T20:44:14.162Z","creation":"2025-04-07T08:41:10.886Z"},"accession":"S-EPMC7373553","cross_references":{"pubmed":["32702848"],"doi":["10.1097/MD.0000000000021060"]}}