biostudies-literatureLi XNational Natural Science Foundation of China1711-1722https://www.ebi.ac.uk/biostudies/studies/S-EPMC7373885biostudies-literatureUnknown7(4)<h4>Aims</h4>This multicentre observational study aimed to prospectively assess the efficacy of left bundle branch area pacing (LBBAP) in heart failure patients with left bundle branch block (LBBB) and compare the 6-month outcomes between LBBAP and biventricular pacing (BVP).<h4>Methods and results</h4>Consecutive patients with LBBB and left ventricular ejection fraction (LVEF) ≤ 35% were prospectively recruited if they had undergone LBBAP as a primary or rescue strategy from three separate centres from March to December 2018. Patients who received BVP in 2018 were retrospectively selected by using 2 to 1 propensity score matching to minimize bias. Implant characteristics and echocardiographic parameters were assessed during the 6-month follow-up. LBBAP procedure succeeded in 81.1% (30/37)ESC heart failureLeft bundle branch area pacing delivery of cardiac resynchronization therapy and comparison with biventricular pacing.PMC737388581970284Li XLi HYao YFan XQiu CHua WWang HZhang SWang ZXie RMa WfalseLeft bundle branch area pacing delivery of cardiac resynchronization therapy and comparison with biventricular pacing.<h4>Aims</h4>This multicentre observational study aimed to prospectively assess the efficacy of left bundle branch area pacing (LBBAP) in heart failure patients with left bundle branch block (LBBB) and compare the 6-month outcomes between LBBAP and biventricular pacing (BVP).<h4>Methods and results</h4>Consecutive patients with LBBB and left ventricular ejection fraction (LVEF) ≤ 35% were prospectively recruited if they had undergone LBBAP as a primary or rescue strategy from three separate centres from March to December 2018. Patients who received BVP in 2018 were retrospectively selected by using 2 to 1 propensity score matching to minimize bias. Implant characteristics and echocardiographic parameters were assessed during the 6-month follow-up. LBBAP procedure succeeded in 81.1% (30/37)2020-01-01T00:00:00Z2020 Aug2025-04-19T01:01:52.569Z2025-04-07T11:56:21.002ZS-EPMC73738853240096710.1002/ehf2.12731