biostudies-literatureUnknown7(4)Gyoten T<h4>Aims</h4>The aim of this study was to compare the outcomes of surgical mitral valve repair or replacement (sMVR) and percutaneous edge-to-edge repair using MitraClip (pMVR) in patients with severe left ventricular dysfunction affected by functional mitral regurgitation (FMR).<h4>Methods and results</h4>We retrospectively identified 132 patients with left ventricular ejection fraction (LVEF) ≦ 30% submitted to sMVR (n = 47) or pMVR (n = 85) for FMR at our centre from January 2013 to December 2017. To adjust for baseline imbalances, we used a propensity score matching by age, logistic EuroSCORE, and left ventricular end-systolic volume. After being matched, MitraClip therapy showed lower perioperative mortality and rate of complications yet increased residual mitral regurgitation (MR) grESC heart failure1781-1790https://www.ebi.ac.uk/biostudies/studies/S-EPMC7373891biostudies-literatureOutcome comparison of mitral valve surgery and MitraClip therapy in patients with severely reduced left ventricular dysfunction.PMC7373891Rochor KJust SFritzsche DGyoten THerwig VSchenk SHarnath AMessroghli DGrimmig OfalseOutcome comparison of mitral valve surgery and MitraClip therapy in patients with severely reduced left ventricular dysfunction.<h4>Aims</h4>The aim of this study was to compare the outcomes of surgical mitral valve repair or replacement (sMVR) and percutaneous edge-to-edge repair using MitraClip (pMVR) in patients with severe left ventricular dysfunction affected by functional mitral regurgitation (FMR).<h4>Methods and results</h4>We retrospectively identified 132 patients with left ventricular ejection fraction (LVEF) ≦ 30% submitted to sMVR (n = 47) or pMVR (n = 85) for FMR at our centre from January 2013 to December 2017. To adjust for baseline imbalances, we used a propensity score matching by age, logistic EuroSCORE, and left ventricular end-systolic volume. After being matched, MitraClip therapy showed lower perioperative mortality and rate of complications yet increased residual mitral regurgitation (MR) gr2020-01-01T00:00:00Z2020 Aug2025-04-19T11:35:29.912Z2025-04-19T11:35:29.912ZS-EPMC73738913244554010.1002/ehf2.12741